HSP90 modulates T2R bitter taste receptor nitric oxide production and innate immune responses in human airway epithelial cells and macrophages
Bitter taste receptors (T2Rs) are G protein-coupled receptors (GPCRs) expressed in various
cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two …
cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two …
Loss of CFTR function is associated with reduced bitter taste receptor-stimulated nitric oxide innate immune responses in nasal epithelial cells and macrophages
Introduction Bitter taste receptors (T2Rs) are G protein-coupled receptors identified on the
tongue but expressed all over the body, including in airway cilia and macrophages, where …
tongue but expressed all over the body, including in airway cilia and macrophages, where …
Nitric oxide production is stimulated by bitter taste receptors ubiquitously expressed in the sinonasal cavity
CH Yan, S Hahn, D McMahon… - American journal of …, 2017 - journals.sagepub.com
Background Bitter taste receptors (T2R) have recently been demonstrated to contribute to
sinonasal innate immunity. One T2R, T2R38, regulates mucosal defense against gram …
sinonasal innate immunity. One T2R, T2R38, regulates mucosal defense against gram …
Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling
I Gopallawa, JR Freund, RJ Lee - Cellular and Molecular Life Sciences, 2021 - Springer
Bitter taste receptors (T2Rs) are GPCRs involved in detection of bitter compounds by type 2
taste cells of the tongue, but are also expressed in other tissues throughout the body …
taste cells of the tongue, but are also expressed in other tissues throughout the body …
Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling
JR Freund, CJ Mansfield, LJ Doghramji… - Journal of Biological …, 2018 - ASBMB
Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many
tissues outside the tongue, have recently become potential therapeutic targets. We have …
tissues outside the tongue, have recently become potential therapeutic targets. We have …
Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components
RJ Lee, B Chen, KM Redding… - Innate …, 2014 - journals.sagepub.com
We previously observed that the human bitter taste receptor T2R38 is an important
component of upper respiratory innate defense because it detects acyl homoserine lactone …
component of upper respiratory innate defense because it detects acyl homoserine lactone …
The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells
DB McMahon, LE Kuek, ME Johnson, PO Johnson… - Cell Calcium, 2022 - Elsevier
Bitter taste receptors (T2Rs) localize to airway motile cilia and initiate innate immune
responses in retaliation to bacterial quorum sensing molecules. Activation of cilia T2Rs …
responses in retaliation to bacterial quorum sensing molecules. Activation of cilia T2Rs …
Bitter and sweet taste receptors regulate human upper respiratory innate immunity
Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including
secreted bacterial products. Here, using human primary sinonasal air-liquid interface …
secreted bacterial products. Here, using human primary sinonasal air-liquid interface …
Bitter and sweet taste receptors in the respiratory epithelium in health and disease
Taste receptors on the tongue communicate information to the brain about the nutrient
content or potential toxicity of ingested foods. However, recent research has now shown that …
content or potential toxicity of ingested foods. However, recent research has now shown that …
The genetics of the bitter taste receptor T2R38 in upper airway innate immunity and implications for chronic rhinosinusitis
NA Cohen - The Laryngoscope, 2017 - Wiley Online Library
Objective Chronic rhinosinusitis (CRS) refractory to therapeutic intervention may involve a
particularly resistant infection known as a bacterial biofilm. Critical to biofilm formation is the …
particularly resistant infection known as a bacterial biofilm. Critical to biofilm formation is the …