Epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal transition (EndMT): role and implications in kidney fibrosis

AS Cruz-Solbes, K Youker - Kidney development and disease, 2017 - Springer
Tubulointerstitial injury is one of the hallmarks of renal disease. In particular, interstitial
fibrosis has a prominent role in the development and progression of kidney injury. Collagen …

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

W Kriz, B Kaissling, M Le Hir - The Journal of clinical …, 2011 - Am Soc Clin Investig
Epithelial-mesenchymal transition (EMT) has become widely accepted as a mechanism by
which injured renal tubular cells transform into mesenchymal cells that contribute to the …

New insights into the role and mechanism of partial epithelial-mesenchymal transition in kidney fibrosis

L Sheng, S Zhuang - Frontiers in physiology, 2020 - frontiersin.org
Epithelial-mesenchymal transition (EMT) is described as the process in which injured renal
tubular epithelial cells undergo a phenotype change, acquiring mesenchymal characteristics …

Epithelial–mesenchymal plasticity in kidney fibrosis

S Hadpech, V Thongboonkerd - genesis, 2024 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) is an important biological process contributing to
kidney fibrosis and chronic kidney disease. This process is characterized by decreased …

Epithelial-mesenchymal transition and its implications for fibrosis

R Kalluri, EG Neilson - The Journal of clinical investigation, 2003 - Am Soc Clin Investig
Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells
found in complex tissues. This dynamic process helps organize the formation of the body …

Partial epithelial-to-mesenchymal transition and other new mechanisms of kidney fibrosis

S Lovisa, M Zeisberg, R Kalluri - Trends in Endocrinology & Metabolism, 2016 - cell.com
Kidney fibrosis is the unavoidable consequence of chronic kidney disease irrespective of the
primary underlying insult. It is a complex phenomenon governed by the interplay between …

Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention

Y Liu - Journal of the American Society of Nephrology, 2004 - journals.lww.com
Mature tubular epithelial cells in adult kidney can undergo epithelial-to-mesenchymal
transition (EMT), a phenotypic conversion that is fundamentally linked to the pathogenesis of …

[PDF][PDF] Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis

M Zeisberg, R Kalluri - Front Biosci, 2008 - article.imrpress.com
[Frontiers in Bioscience 13, 6991-6998, May 1, 2008] 6991 Fibroblasts emerge via epithelial-mesenchymal
transition in chronic ki Page 1 [Frontiers in Bioscience 13, 6991-6998, May 1, 2008] 6991 …

Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease

J He, Y Xu, D Koya, K Kanasaki - Clinical and experimental nephrology, 2013 - Springer
All types of progressive chronic kidney disease (CKD) inevitably induce renal fibrosis, the
hallmark of which is the activation and accumulation of a large number of matrix-producing …

New insights into epithelial-mesenchymal transition in kidney fibrosis

Y Liu - Journal of the American Society of Nephrology, 2010 - journals.lww.com
Abstract Epithelial-mesenchymal transition (EMT), a process by which differentiated
epithelial cells undergo a phenotypic conversion that gives rise to the matrix-producing …