Chronic exposure to elevated saturated free fatty acid (FFA) levels has been shown to
induce endoplasmic reticulum (ER) stress that may contribute to promoting pancreatic β-cell …

Both stimulatory and detrimental effects of NEFAs (non-esterified fatty acids) on pancreatic β-
cells have been recognized. Acute exposure of the pancreatic β-cell to high glucose …

Evidence for “lipotoxicity,” ie, negative effects of fatty acids (FA) on pancreatic β-cells is
incomplete. Here, we tested whether non-toxic concentrations of FA potentiate toxic effects …

Abstract Background/Aims: The polyunsaturated fatty acid arachidonic acid (AA) has been
implicated in β-cell defence mechanisms and prostaglandin (PG) products of …

Background While the effect of fatty acids and ectopic triglyceride storage in pancreatic beta
cells has been well‐defined, only limited information is available on alpha cells. This study …

Lipid accumulation in pancreatic β-cells is thought to cause its dysfunction and/or
destruction via apoptosis. Our studies show that incubation of the β-cell line RINm5F with the …

Prolonged exposure of isolated islets to supraphysiologic concentrations of palmitate
decreases insulin gene expression in the presence of elevated glucose levels. This study …

BACKGROUND AND PURPOSE Free fatty acids are important metabolic fuels for
mammalian cells but, recently, it has become clear that they can also fulfil signalling …

Long-term exposure to fatty acids (FA) inhibits B-cell function. We tested whether the
inhibitory effects are associated with increased islet triglycerides (TG). Rat pancreatic islets …

Long-term exposure of the pancreatic β cells to free fatty acid (FFA) reportedly inhibits
glucose-stimulated insulin secretion. We here studied the impact of FFA on glucose and lipid …