Long-term exposure of beta cells to saturated fatty acids impairs insulin secretion and
increases apoptosis. In contrast, unsaturated fatty acids protect beta-cells from the long-term …

There are strong links between obesity, elevated free fatty acids, and type 2 diabetes.
Specifically, the saturated fatty acid palmitate has pleiotropic effects on β-cell function and …

Aims/hypothesis Although the substitution of saturated fatty acids with oleate has been
recommended in the management of type 2 diabetes mellitus, the mechanisms by which …

Long-term exposure to fatty acids impairs β-cell function in type 2 diabetes, but little is known
about the chronic effects of fatty acids on α-cells. We therefore studied the prolonged impact …

Aims/hypothesis Whether excess glucose (glucotoxicity) and excess non-esterified fatty
acids (lipotoxicity) act synergistically or separately to alter beta-cell function on Type 2 …

Fatty acids, acetylcholine, and GLP-1 enhance insulin secretion in a glucose-dependent
manner. However, the interplay between glucose, fatty acids, and the neuroendocrine …

Pancreatic β-cells are particularly susceptible to fatty-acid-induced endoplasmic reticulum
(ER) stress and apoptosis. To understand how β-cells sense fatty acid stimuli and translate …

Background/Aims: Elevated levels of non-esterified fatty acids (NEFAs) are under suspicion
to mediate β-cell dysfunction and β-cell loss in type 2 diabetes, a phenomenon known as …

OBJECTIVES: We previously showed that prior oral supplementation of oils rich in ω-3,
eicosapentaenoic acid and docosahexaenoic acid, and ω-6, γ-linolenic acid and …

Pancreatic β-cell proliferation is infrequent in adult humans and is not increased in type 2
diabetes despite obesity and insulin resistance, suggesting the existence of inhibitory …