Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes

D Zhang, H Yang, X Kong, K Wang… - American Journal …, 2011 - journals.physiology.org
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. To date, the
molecular mechanisms of DN remain largely unclear. The present study aimed to identify …

[HTML][HTML] Identification of novel key molecular signatures in the pathogenesis of experimental diabetic kidney disease

M Diao, Y Wu, J Yang, C Liu, J Xu, H Jin… - Frontiers in …, 2022 - frontiersin.org
Diabetic kidney disease (DKD) is a long-term major microvascular complication of
uncontrolled hyperglycemia and one of the leading causes of end-stage renal disease …

[HTML][HTML] Metabonomic analysis of potential biomarkers and drug targets involved in diabetic nephropathy mice

T Wei, L Zhao, J Jia, H Xia, Y Du, Q Lin, X Lin, X Ye… - Scientific reports, 2015 - nature.com
Diabetic nephropathy (DN) is one of the lethal manifestations of diabetic systemic
microvascular disease. Elucidation of characteristic metabolic alterations during diabetic …

[HTML][HTML] Multi-omics analysis of diabetic nephropathy reveals potential new mechanisms and drug targets

Q Sha, J Lyu, M Zhao, H Li, M Guo, Q Sun - Frontiers in genetics, 2020 - frontiersin.org
Diabetic nephropathy (DN) is one of the most common diabetic complications, which is the
major course of end-stage renal disease (ESRD). However, the systematical molecular …

[HTML][HTML] Dynamic phenotypes and molecular mechanisms to understand the pathogenesis of diabetic nephropathy in two widely used animal models of type 2 …

Y Liu, H Huang, R Gao, Y Liu - Frontiers in cell and developmental …, 2020 - frontiersin.org
Objective We aimed to characterize the pathogenesis of diabetic nephropathy (DN) in two
commonly used type 2 diabetes mellitus (T2DM) animal models and explore the preliminary …

[HTML][HTML] Pathophysiologic mechanisms and potential biomarkers in diabetic kidney disease

CY Jung, TH Yoo - Diabetes & Metabolism Journal, 2022 - ncbi.nlm.nih.gov
Although diabetic kidney disease (DKD) remains the leading cause of end-stage kidney
disease eventually requiring chronic kidney replacement therapy, the prevalence of DKD …

[HTML][HTML] Identification of novel biomarker for early detection of diabetic nephropathy

KS Kim, JS Lee, JH Park, EY Lee, JS Moon, SK Lee… - Biomedicines, 2021 - mdpi.com
Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus.
After development of DN, patients will progress to end-stage renal disease, which is …

[HTML][HTML] What's new in the molecular mechanisms of diabetic kidney disease: recent advances

K Watanabe, E Sato, E Mishima, M Miyazaki… - International journal of …, 2022 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease, including end-
stage kidney disease, and increases the risk of cardiovascular mortality. Although the …

[HTML][HTML] Insight into the Molecular Mechanism of Diabetic Kidney Disease and the Role of Metformin in Its Pathogenesis

M Kleibert, P Zygmunciak, K Łakomska, K Mila… - International Journal of …, 2023 - mdpi.com
Diabetic kidney disease (DKD) is one of the leading causes of death among patients
diagnosed with diabetes mellitus. Despite the growing knowledge about the pathogenesis of …

[HTML][HTML] Serum metabolomics benefits discrimination kidney disease development in type 2 diabetes patients

X Peng, X Wang, X Shao, Y Wang, S Feng… - Frontiers in …, 2022 - frontiersin.org
Background: Diabetic kidney disease (DKD) is the primary cause of end-stage renal
disease, raising a considerable burden worldwide. Recognizing novel biomarkers by …