Ferulic acid pretreatment mitigates MPTP-induced motor impairment and histopathological alterations in C57BL/6 mice

S Nagarajan, DR Chellappan… - Pharmaceutical …, 2015 - Taylor & Francis
Context: Ferulic acid (FA) is a potent ubiquitous plant antioxidant found in cereals such as
brown rice, whole wheat, and oats. Phytochemical-based antioxidants are shown to be …

Neuroprotective potential of ferulic acid in the rotenone model of Parkinson's disease

S Ojha, H Javed, S Azimullah… - Drug design …, 2015 - Taylor & Francis
Parkinson's disease (PD) is a chronic, progressive, and the second most common form of
neurodegenerative disorders. In order to explore novel agents for the treatment of PD, in the …

Ferulic Acid Ameliorates MPP+/MPTP-Induced Oxidative Stress via ERK1/2-Dependent Nrf2 Activation: Translational Implications for Parkinson Disease Treatment

X Li, J Zhang, H Rong, X Zhang, M Dong - Molecular neurobiology, 2020 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder closely associated with oxidative
stress. The biochemical and cellular alterations that occur after cell and mouse treatment …

The neuroprotective effects of Ferulic acid in toxin-induced models of Parkinson's disease: a review

S Hassani, A Esmaeili - Ageing Research Reviews, 2024 - Elsevier
Parkinson's disease is predominantly caused by dopaminergic neuron loss in the substantia
nigra pars compacta and the accumulation of alpha-synuclein protein. Though the general …

[HTML][HTML] Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice

SF Xu, YH Zhang, S Wang, ZQ Pang, YG Fan, JY Li… - Redox biology, 2019 - Elsevier
Brain iron accumulation is common in patients with Parkinson's disease (PD). Iron chelators
have been investigated for their ability to prevent neurodegenerative diseases with features …

Phloretin attenuates behavior deficits and neuroinflammatory response in MPTP induced Parkinson's disease in mice

G Zhang, G Yang, J Liu - Life sciences, 2019 - Elsevier
Neuroinflammation is one of the significant neuropathological conditions in Parkinson's
disease (PD) which is due to microglial and astrocytes activation leads to progressive …

Ceftriaxone mediated rescue of nigral oxidative damage and motor deficits in MPTP model of Parkinson's disease in rats

R Bisht, B Kaur, H Gupta, A Prakash - Neurotoxicology, 2014 - Elsevier
Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopamine
neurons in the substantia nigra pars compacta along with decreased striatal dopamine …

Fucoxanthin attenuates behavior deficits and neuroinflammatory response in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced Parkinson's disease in mice

G Sun, T Xin, R Zhang, C Liu, Q Pang - Pharmacognosy Magazine, 2020 - phcog.com
Background: Parkinson's disease (PD) is one of the foremost neurological disorders which is
differentiated next to the progressive dopamine (DA) loss, especially in the area of …

Paeoniflorin and Plycyrrhetinic Acid Synergistically Alleviate MPP+/MPTP-Induced Oxidative Stress through Nrf2-Dependent Glutathione Biosynthesis Mechanisms

H Dong, J Zhang, H Rong, X Zhang… - ACS Chemical …, 2021 - ACS Publications
Recently, combination therapy has proven to be an effective strategy for treating polygenic/
multifactorial/complex disorder such as Parkinson's disease (PD). Here, we hypothesized …

Feruloylated oligosaccharides ameliorate MPTP-induced neurotoxicity in mice by activating ERK/CREB/BDNF/TrkB signalling pathway

Y Ding, M Zhou, R Zheng, R Ma, J Deng, W Hao… - Phytomedicine, 2023 - Elsevier
Abstract Background Feruloylated oligosaccharides (FOs) are natural esterification products
of ferulic acid and oligosaccharides. Study Design In this study, we examined whether FOs …