The mechanisms underlying mucus-associated pathologies in cystic fibrosis (CF) remain
obscure. However, recent studies indicate that CF transmembrane conductance regulator …

Cystic fibrosis (CF) is caused by a nonfunctional chloride and bicarbonate ion channel (CF
transmembrane regulator [CFTR]), but the link to the phenomenon of stagnant mucus is not …

BACKGROUND & AIMS: Duodenal bicarbonate secretion is an important factor in epithelial
protection. The role of the cystic fibrosis transmembrane conductance regulator (CFTR) in …

The invitation to present the 2010 Hans Ussing lecture for the Epithelial Transport Group of
the American Physiological Society offered me a unique, special, and very surprising …

Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

1 Most segments of the gastrointestinal tract secrete HCO3−, but the molecular nature of the
secretory mechanisms has not been identified. We had previously speculated that the …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP and cGMP-
regulated chloride channel critical to the regulation of intestinal fluid, chloride, and …

Key points• HCO3− is required for gel‐forming mucins to form normal mucus, but how?• Two
apparently separate signalling pathways are activated concurrently to bring mucus formation …

A central function of cystic fibrosis transmembrane conductance regulator (CFTR)-
expressing tissues is the secretion of fluid containing 100–140 mmHCO 3−. High levels of …

The role of the cystic fibrosis transmembrane conductance regulator (CFTR) in duodenal
alkaline secretion has not been directly examined. The aims of this series of experiments …