Abstract Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is an enzyme that detoxifies
aldehydes by converting them to carboxylic acids. ALDH2 deficiency is known to increase …

Aims Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective
pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied …

Previous studies demonstrated that aldehyde dehydrogenase 2 (ALDH2) rs671
polymorphism, which eliminates ALDH2 activity down to 1%-6%, is a susceptibility gene for …

Previous evidence has indicated a beneficial role for aldehyde dehydrogenase 2 (ALDH2)
in suppressing atherosclerotic plaque progression and instability. However, the underlying …

Mitochondrial aldehyde dehydrogenase (ALDH-2) reduces reactive oxygen species (ROS)
formation related to toxic aldehydes; additionally, it provides a bioactivating pathway for …

Vascular smooth muscle cell (VSMC) proliferation promotes intimal hyperplasia (IH) in
occluding vascular diseases. Here we identified a positive role of ALDH1A3 (an aldehyde …

Abstract Aldehyde dehydrogenase 2 (ALDH2) is a key mitochondrial enzyme in the
metabolism of aldehydes and may have beneficial cardiovascular effects for conditions such …

Common liver tissue damage is mainly due to the accumulation of toxic aldehydes in lipid
peroxidation under oxidative stress. Cumulative toxic aldehydes in the liver can be …

Reactive carbonyl species (RCS) are spontaneously formed in the metabolism and modify
and impair the function of DNA, proteins and lipids leading to several organ complications …

Reactive lipid aldehydes are implicated in the pathogenesis of various oxidative stress-
mediated diseases, including non-alcoholic steatohepatitis, atherosclerosis, Alzheimer's and …