The CLOCK trial, a double‐blinded randomized controlled trial: Trisodium citrate 30% and minocycline 3 mg/mL plus EDTA 30 mg/mL are effective and safe for …

MVSJ Luiz, C Scavone, C Tzanno - Hemodialysis International, 2017 - Wiley Online Library
Introduction: Poor blood flow rate (PF) is highly prevalent among CKD 5D patients with long‐
term central venous catheters. Heparin catheter lock solutions are commonly used to …

Hemodialysis catheter locking solutions and the prevention of catheter dysfunction: a meta-analysis

K Chapla, BP Oza-Gajera, AS Yevzlin… - The Journal of …, 2015 - journals.sagepub.com
Purpose Tunneled dialysis catheters (TDCs) continue to be utilized at an alarming rate
despite having a higher rate of complications when compared to fistulas and grafts. One of …

Catheter Outcomes in the Short‐term Inpatient Setting: A Controlled Quality Improvement Study Comparing Citrate and Heparin Lock

S Parikh, R Nijmeh, S Van Cleef… - Seminars in …, 2012 - Wiley Online Library
Heparin and citrate are used as catheter lock solutions to reduce risk of catheter dysfunction
and infection in hemodialysis. There is a paucity of data comparing these two locks in the …

Risk factors associated with hemodialysis central venous catheter malfunction; a retrospective analysis of a randomized controlled trial

DR Ward, LM Moist, JM MacRae… - … Journal of Kidney …, 2014 - journals.sagepub.com
Background: We previously reported a reduction in central venous catheter (CVC)
malfunction when using once-weekly recombinant tissue-plasminogen activator (rt-PA) as a …

Reevaluation of lock solutions for Central venous catheters in hemodialysis: a narrative review

Y Wang, X Sun - Renal Failure, 2022 - Taylor & Francis
Background A significant proportion of incident and prevalent hemodialysis patients have
central venous catheters for vascular access. No consensus is available on the prevention of …

Catheter lock solutions: it's time for a change

S Mandolfo, S Borlandelli, A Elli - The Journal of Vascular …, 2006 - journals.sagepub.com
In recent years, the number of patients on hemodialysis (HD) with central vascular catheters
(CVCs) has grown. However, CVC use is often associated with an important risk for catheter …

A novel antimicrobial and antithrombotic lock solution for hemodialysis catheters: a multi-center, controlled, randomized trial

DG Maki, SR Ash, RK Winger, P Lavin… - Critical care …, 2011 - journals.lww.com
Background and Purpose: Catheter-related bloodstream infection is the greatest threat to the
safety of patients on hemodialysis. Catheter lock solutions containing heparin have been …

Sodium citrate 4% versus heparin as a lock solution in hemodialysis patients with central venous catheters

CK Yon, CL Low - American journal of health-system pharmacy, 2013 - academic.oup.com
Purpose The effects of heparin versus sodium citrate 4% as a lock solution on catheter-
related infections (CRIs), catheter patency, and hospitalizations in long-term hemodialysis …

Citrate versus heparin lock for hemodialysis catheters: a systematic review and meta-analysis of randomized controlled trials

Y Zhao, Z Li, L Zhang, J Yang, Y Yang, Y Tang… - American journal of …, 2014 - Elsevier
Background Citrate solution has been suggested as an effective and safe catheter lock in
hemodialysis. However, whether a citrate lock is superior to a heparin lock in preventing …

Comparative effectiveness of 30% trisodium citrate and heparin lock solution in preventing infection and dysfunction of hemodialysis catheters: a randomized …

F Correa Barcellos, B Pereira Nunes, L Jorge Valle… - Infection, 2017 - Springer
Background Central venous catheters (CVC) are the only option when hemodialysis is
needed for patients without definitive vascular access. However, CVC is associated with …