Detection of polymorphisms in the 5′-flanking region of the gene for apolipoprotein (a)

A Ichinose, M Kuriyama - Biochemical and biophysical research …, 1995 - Elsevier
Concentration of lipoprotein (a) in plasma is inherited in an autosomal co-dominant manner
and its high concentration leads to atherothrombotic disease. Nucleotide sequence analysis …

Plasma lipoprotein (a) levels and expression of the apolipoprotein (a) gene are dependent on the nucleotide polymorphisms in its 5'-flanking region.

K Suzuki, M Kuriyama, T Saito… - The Journal of clinical …, 1997 - Am Soc Clin Investig
The apolipoprotein (a)(apo [a]) gene encodes a protein component of lipoprotein (a)[Lp (a)]
whose plasma levels vary widely among individuals. Hyper-Lp (a)-emia constitutes a risk …

A pentanucleotide repeat polymorphism in the 5'control region of the apolipoprotein (a) gene is associated with lipoprotein (a) plasma concentrations in Caucasians.

M Trommsdorff, S Köchl, A Lingenhel… - The Journal of …, 1995 - Am Soc Clin Investig
The enormous interindividual variation in the plasma concentrations of the atherogenic
lipoprotein (a)[Lp (a)] is almost entirely controlled by the apo (a) locus on chromosome 6q26 …

Sequence polymorphisms in the apolipoprotein (a) gene. Evidence for dissociation between apolipoprotein (a) size and plasma lipoprotein (a) levels.

JC Cohen, G Chiesa, HH Hobbs - The Journal of clinical …, 1993 - Am Soc Clin Investig
Apolipoprotein (a)[apo (a)], an apolipoprotein unique to lipoprotein (a)[Lp (a)], is highly
polymorphic in size. Previous studies have indicated that the size of the apo (a) gene tends …

The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration

HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a quantitative trait in human plasma. Lp (a) consists of a
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …

The apolipoprotein (a) gene resides on human chromosome 6q26–27, in close proximity to the homologous gene for plasminogen

SL Frank, I Klisak, RS Sparkes, T Mohandas… - Human genetics, 1988 - Springer
Summary Apolipoprotein (a)[apo (a)], the glycoprotein associated with the lipoprotein (a)[Lp
(a)] subfraction of plasma lipoproteins, has been shown to exhibit heritable molecular weight …

Expressed hypervariable polymorphism of apolipoprotein (a).

MI Kamboh, RE Ferrell, BA Kottke - American journal of human …, 1991 - ncbi.nlm.nih.gov
Elevated plasma lipoprotein (a)(LP (a] levels are an independent predictor of the
development of premature atherosclerosis in humans. The LP (a) particle consists of two …

High degree of genetic polymorphism in apolipoprotein (a) associated with plasma lipoprotein (a) levels in Japanese and Chinese populations

S Kikuchi, A Nakagawa, K Kobayashi, L Li, H Yanagi… - Human genetics, 1993 - Springer
We have developed a sensitve, high-resolution method for the analysis of the apolipoprotein
(a)[apo (a)] isoforms using sodium dodecyl sulfate (SDS)-agarose/gradient polyacrylamide …

Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus.

CA DeMeester, X Bu, RJ Gray, AJ Lusis… - American journal of …, 1995 - ncbi.nlm.nih.gov
Abstract Lipoprotein (a)(Lp [a]) is a cholesterol-rich lipoprotein resembling LDL but also
containing a large polypeptide designated apolipoprotein (a)(apo [a]). Its levels are highly …

Sequence polymorphisms in the apolipoprotein (a) gene and their association with lipoprotein (a) levels and myocardial infarction. The ECTIM Study

L Brazier, L Tiret, G Luc, D Arveiler, JB Ruidavets… - Atherosclerosis, 1999 - Elsevier
Lp (a) concentrations are largely determined by apo (a) isoform size, but several studies
have shown that apo (a) isoforms could not entirely explain the increase of Lp (a) levels …