Recent observations in the field of signal transduction suggest that where a protein is
located within a cell can be as important as its activity measured in solution for activation of …

In many cellular signaling pathways, key components form clusters at the cell membrane.
Although much work has focused on the mechanisms behind such cluster formation, the …

Abstract Information transmission in cells occurs through complex networks of proteins and
genes and is relayed through cascades of biochemical modifications, which are typically …

Many key biochemical reactions that mediate signal transduction in cells occur at the cell
membrane, yet how the two-dimensional membrane environment influences the collective …

Systems biology modeling of signal transduction pathways traditionally employs ordinary
differential equations, deterministic models based on the assumptions of spatial …

Emerging evidence indicates that complex spatial gradients and (micro) domains of
signalling activities arise from distinct cellular localization of opposing enzymes, such as a …

Spatial heterogeneity is a hallmark of living systems, even at the molecular scale in
individual cells. A key example is the partitioning of membrane-bound proteins via lipid …

Many reactions within the cell occur only in specific intracellular regions. Such local reaction
networks give rise to microdomains of activated signaling components. The dynamics of …

Push–pull networks are ubiquitous in signal transduction pathways in both prokaryotic and
eukaryotic cells. They allow cells to strongly amplify signals via the mechanism of zero-order …

The temporal and stationary behavior of protein modification cascades has been extensively
studied, yet little is known about the spatial aspects of signal propagation. We have …