Pain in diabetes is a common debilitating condition for which pathophysiology remains
poorly understood. To evaluate the underlying mechanisms, we used intravenous injection …

Painful neuropathy is common in human diabetes. In rats, experimental diabetes results in
altered pain sensitivity. We examined the effect of chronic insulin treatment on diabetes …

Streptozotocin (STZ)-induced diabetes in the rat has been increasingly used as a model of
painful diabetic neuropathy to assess the efficacies of potential analgesic agents. We have …

A modified von Frey filament test and an algesiometer paw pressure test were used to
measure mechanical nociceptive withdrawal thresholds of the hind limb of control rats and …

This study used streptozotocin (STZ; 50 mg/kg ip) diabetic rats and monitored weekly
thermal and mechanical nociceptive thresholds for 8 weeks diabetes. Rats developed …

Painful peripheral neuropathy is a common secondary complication of diabetes. The
streptozotocin (STZ)‐induced diabetic rat is the most commonly employed animal model …

The triggers and pathogenesis of peripheral diabetic neuropathy are poorly understood, and
this study evaluated the role of insulinopenia in nociceptive abnormalities in the …

Painful diabetic neuropathy is one of the most common complications of insulin-dependent
diabetes in man. Conflicting results have been obtained in experimentally diabetic animals …

We report herein that streptozotocin (STZ)-induced diabetes selectively alters the
nociceptive threshold with respect to noxious mechanical stimuli. Mice were rendered …

Abstract Objective. As the Diabetes Control and Complications Trial showed that intensive
glycemic control in patients with Type 1 diabetes decreased the risk of development of long …