Imaging and CSF studies in the preclinical diagnosis of Alzheimer's disease

MJ De Leon, L Mosconi, K Blennow… - Annals of the New …, 2007 - Wiley Online Library
It is widely believed that the path to early and effective treatment for Alzheimer's disease
(AD) requires the development of early diagnostic markers that are both sensitive and …

MRI and CSF studies in the early diagnosis of Alzheimer's disease

MJ De Leon, S DeSanti, R Zinkowski… - Journal of internal …, 2004 - Wiley Online Library
The main goal of our studies has been to use MRI, FDG‐PET, and CSF biomarkers to
identify in cognitively normal elderly (NL) subjects and in patients with mild cognitive …

Current challenges for the early detection of Alzheimer's disease: brain imaging and CSF studies

R Mistur, L Mosconi, S De Santi… - Journal of clinical …, 2009 - synapse.koreamed.org
The development of prevention therapies for Alzheimer's disease (AD) would greatly benefit
from biomarkers that are sensitive to the subtle brain changes that occur in the preclinical …

Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment

MJ De Leon, S DeSanti, R Zinkowski, PD Mehta… - Neurobiology of …, 2006 - Elsevier
The diagnosis of Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI)
is limited because it is based on non-specific behavioral and neuroimaging findings. The …

Early detection of Alzheimer's disease using neuroimaging

L Mosconi, M Brys, L Glodzik-Sobanska… - Experimental …, 2007 - Elsevier
Neuroimaging is being increasingly used to complement clinical assessments in the early
detection of Alzheimer's disease (AD). Structural magnetic resonance imaging (MRI) and …

Neuroimaging as a marker of the onset and progression of Alzheimer's disease

JC Masdeu, JL Zubieta, J Arbizu - Journal of the neurological sciences, 2005 - Elsevier
Several neuroimaging techniques are promising tools as early markers of brain pathology in
Alzheimer's disease (AD). On structural MRI, atrophy of the entorhinal cortex is present …

Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging

L Mosconi, V Berti, L Glodzik, A Pupi… - Journal of …, 2010 - content.iospress.com
The development of prevention therapies for Alzheimer's disease (AD) would greatly benefit
from biomarkers that are sensitive to subtle brain changes occurring in the preclinical stage …

Neuroimaging and other biomarkers for Alzheimer's disease: the changing landscape of early detection

SL Risacher, AJ Saykin - Annual review of clinical psychology, 2013 - annualreviews.org
The goal of this review is to provide an overview of biomarkers for Alzheimer's disease (AD),
with emphasis on neuroimaging and cerebrospinal fluid (CSF) biomarkers. We first review …

Imaging is superior to cognitive testing for early diagnosis of Alzheimer's disease

E Zamrini, S De Santi, M Tolar - Neurobiology of aging, 2004 - Elsevier
Alzheimer's disease (AD) starts at a molecular level possibly decades earlier than could be
detected by neuropsychological tests (NPTs). Neuropathological and neuroimaging data …

Meta-analysis of CSF and MRI biomarkers for detecting preclinical Alzheimer's disease

B Schmand, HM Huizenga, WA Van Gool - Psychological medicine, 2010 - cambridge.org
BackgroundAbnormal levels of biomarkers in cerebrospinal fluid (CSF) and atrophy of
medial temporal lobe (MTL) structures on magnetic resonance imaging (MRI) are being …