There is a tremendous need for exposure biomarkers, which need to function as
intermediate end-points in cancer chemoprevention studies. Likely candidates include …

The most efficient strategy for chemoprevention clinical trials are short‐term studies which
focus on surrogate endpoint biomarkers (SEBs) in high‐risk target populations. High‐grade …

The marked discrepancy between the prevalence of preclinical prostate cancer and the
incidence of clinically manifest disease indicates a long latency phase and significant …

High-grade prostatic intraepithelial neoplasia (HGPIN) is commonly encountered on
prostate needle biopsies and, based on epidemiologic, molecular, and animal models, has …

High-grade prostatic intraepithelial neoplasia (HGPIN) is a precursor to invasive prostate
cancer observed as an isolated entity in a growing subset of men undergoing prostate …

Prostate cancer chemoprevention can be defined as the administration of natural and
synthetic agents (pharmaceuticals, biologics, and micronutrients) to prevent initiation, inhibit …

High-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor of
prostatic adenocarcinoma according to virtually all available evidence. This lesion is …

Introduction: High-grade prostatic intraepithelial neoplasia (HGPIN) is generally accepted to
be a precursor lesion of prostate cancer. The likely outcome of isolated low-grade PIN …

Purpose High-grade prostatic intraepithelial neoplasia (HGPIN) is a potential precursor of
prostate cancer (PCa), and patients with HGPIN are at high risk for PCa development …

Use of high-grade prostatic intraepithelial neoplasia (PIN) as an intermediate biomarker for
prostate cancer requires additional data concerning its natural biological behaviour …