Autism spectrum disorder (ASD) and intellectual disability (ID) are neurodevelopmental
disorders with large genetic components, but identification of pathogenic genes has …

Autism is a heterogeneous neurodevelopmental syndrome with a complex genetic etiology.
It is still not clear whether autism comprises a vast collection of different disorders akin to …

Understanding the neurobiological processes by which genotypes become phenotypes,
along with the advances in developmental neuroscience and neuronal networks at the …

Genetic studies are refining our understanding of neurodevelopmental mechanisms in
autism. Some autism-related mutations appear to disrupt genes regulated by neuronal …

Highlights•High throughput genomic methods are rapidly increasing the pool of ASD
genes.•Heterogeneity, pleiotropy, and brain complexity complicate translation to …

Autism is a particularly complex disorder when considered from virtually any methodological
framework, including the perspective of human genetics. We first present a review of the …

Although much progress has been made in determining the cognitive profile of strengths
and weaknesses that characterise individuals with autism spectrum disorders (ASDs), there …

Autism Spectrum Disorder (ASD) is one of the most prevalent neurodevelopmental
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …

Highlights•Exome sequencing on unprecedented scale has identified 400 genes associated
with ASD and NDD.•Functional networks disrupted in NDD converge on distinct …

Autism spectrum disorders (ASDs) are a clinically complex group of childhood disorders that
have firm evidence of an underlying genetic etiology. Many techniques have been used to …