Astrocytes are critical for neuronal redox homeostasis providing them with cysteine needed
for glutathione synthesis. In this study, we demonstrate that the astrocytic redox response …

Alzheimer's disease is widely held to be associated with oxidative stress due, in part, to the
action of amyloid bpeptide (Ab). We observed that Ab 25–35 induced an increase in reactive …

It has been previously reported that Alzheimer's amyloid β protein (Aβ) induces reactive
astrocytosis in culture. In the present study, we found that Aβ potently inhibits cellular redox …

Glutathione is the major low-molecular weight thiol of eukaryotic cells. It is central to one of
the two major NADPH-dependent reducing systems and is likely to play a role in combating …

Redox changes within neurones are increasingly being implicated as an important
causative agent in brain ageing and neurodegenerative diseases such as amyotrophic …

Oxidative stress has been implicated to play a crucial role in the pathogenesis of a number
of diseases, including neurodegenerative disorders, cancer, and ischemia, just to name a …

This review discusses the current understanding of cysteine and glutathione redox balance
in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte …

Significance: Alzheimer disease (AD) is an age-related neurodegenerative disease. AD is
characterized by progressive cognitive impairment. One of the main histopathological …

Alzheimer's disease (AD) is a devastating age-related neurodegenerative disease. Age is
the main risk factor for sporadic AD, which is the most prevalent type. Amyloid-β peptide (Aβ) …

Mechanism of amyloid β-peptide (Aβ) toxicity in cultured neurons involves the development
of oxidative stress in the affected cells. A significant increase in protein carbonyl formation …