In this overview, the present knowledge about the effects of nicotine on neurotransmitter
release in the central nervous system has been evaluated. Five characteristics relating to …

Background Cigarette smoking is associated with metabolite abnormalities in anterior brain
regions, but it is unclear if these abnormalities are apparent in other regions. Additionally …

Alteration in glutamate neurotransmission has been found to mediate the development of
drug dependence, including nicotine. We and others, through using western blotting, have …

BACKGROUND: Cigarette smoking is the leading preventable cause of death.
Unfortunately, the majority of smokers who attempt to quit smoking relapse within weeks …

For the smoker, nicotine has a positive effect on attention, cognition and mood. Conversely,
nicotine abstinence is characterized by uncomfortable psychological effects such as …

The present paper proposes a model for the identification and the validation of brain
processes and mechanisms underlying smokers' cue reactivity. Smoking behaviour is …

We investigated the impact of the administration of a tyrosine-depleting amino acid mixture
compared to a balanced mixture on measures of mood, craving and selective processing of …

Glutamate neurotransmission, and particularly metabotropic glutamate (mGlu) 2/3 receptors
are implicated in behaviors of relevance to the addictive properties of nicotine. In laboratory …

Nicotine abuse and addiction is a major health liability. Nicotine, an active alkaloid in
tobacco, is self-administered by animals and produces cellular adaptations in brain regions …

There is abundant evidence to show that nicotine is the principal addictive component of
tobacco smoke. The results of laboratory studies have shown that nicotine has many of the …