Rationale The mechanisms mediating tobacco addiction remain elusive. Nicotine, the
psychoactive component in tobacco, is generally believed to be the main cause of reward …

Although nicotine is generally considered to be the main psychoactive component of
tobacco, growing evidence highlights the importance of nonnicotine compounds in smoking …

Tobacco use has one of the highest rates of addiction of any abused drug. Paradoxically, in
animal models, nicotine appears to be a weak reinforcer. We report here that the inhibition of …

Nicotine is the main psychoactive ingredient in tobacco and its rewarding effects are
considered primarily responsible for persistent tobacco smoking and relapse. Although …

Although nicotine is considered to be responsible for the addictive properties of tobacco,
growing evidence underlines the importance of non‐nicotine components in smoking …

Nicotine, the primary psychoactive compound in tobacco, is responsible for the addictive
effects of smoking; however, there is a paucity of information indicating whether the …

Introduction Although nicotine is the primary reinforcing constituent in cigarettes, there is
evidence that other constituents in cigarette smoke may interact with nicotine to reinforce …

Our current study aims to evaluate the mechanisms of tranylcypromine (TCP)-mediated
enhancement of nicotine self-administration. We replicated our previous findings which …

Abstract The Food and Drug Administration (FDA) has the authority to regulate cigarette
smoke constituents, and a reduction in nicotine content might benefit public health by …

Nicotine is the major neuroactive compound of tobacco, which has, by itself, weak
reinforcing properties. It is known that levels of the enzymes monoamine oxidase A (MAO-A) …