Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cells

SS Pierangeli, EN Harris - Lupus, 2003 - journals.sagepub.com
The association of antiphospholipid (aPL) antibodieswith thrombosisin patientswith
antiphospholipid syndrome (APS) is well documented in humans and in animal studies …

Lysophosphatidylcholine is involved in the antigenicity of oxidized LDL

R Wu, YH Huang, LS Elinder… - … thrombosis, and vascular …, 1998 - Am Heart Assoc
Lysophosphatidylcholine (LPC) is formed by hydrolysis of PC in low density lipoprotein
(LDL) and cell membranes by phospholipase A2 or by oxidation. Oxidized (ox) LDL …

[PDF][PDF] Atherosclerosis, antiphospholipid syndrome, and antiphospholipid antibodies

D Nicolo, AS Varadhachary, M Monestier - Front Biosci, 2007 - article.imrpress.com
Introduction 3. Immunology of atherosclerosis 3.1. Oxidative modification of LDL 3.2. Lesion
development and composition 3.3. Immune mechanisms in atherosclerosis 4. Antibodies in …

Effect of cardiolipin oxidation on solid-phase immunoassay for antiphospholipid antibodies

M Schlame, I Haller, LR Sammaritano… - Thrombosis and …, 2001 - thieme-connect.com
Diagnostic assays for antiphospholipid antibodies are routinely performed on microtitre
plates coated with cardiolipin. Here we show that contact between cardiolipin and NUNC …

Oxidized low-density lipoprotein as a risk factor of thrombosis in antiphospholipid syndrome

E Matsuura, K Kobayashi, T Koike, Y Shoenfeld… - Lupus, 2003 - journals.sagepub.com
β2-Glycoprotein I (β2-GPI) is a major antigen for anticardiolipin antibodies (aCL, Abs)
present in patients with antiphospholipidsyndrome (APS). We recently reported that oxidized …

Antiphospholipid antibodies in patients with coronary artery disease: new cardiac risk factors?

TP Greco, ANNM CONTI‐KELLY… - Annals of the New …, 2007 - Wiley Online Library
Antiphospholipid antibodies (aPL) have been implicated in the pathogenesis of coronary
artery disease (CAD). We evaluated the presence of aPL in patients with chest pain/acute …

Identification and characterization of a peptide mimetic that may detect a species of disease‐associated anticardiolipin antibodies in patients with the antiphospholipid …

S Visvanathan, JK Scott, KK Hwang… - Arthritis & …, 2003 - Wiley Online Library
Objective To test the feasibility of applying a mimetic (specific for a patient‐derived
prothrombotic anticardiolipin antibody [aCL]) to study the homologous, disease‐associated …

Anticardiolipin antibodies and coronary heart disease

DA Tsakiris, GA Marbet, F Burkart… - European heart …, 1992 - academic.oup.com
Arterial or venous thrombotic events have been described as complications in patients with
positive anticardiolipin antibodies (aCL), affecting various organs including the heart. In …

Evidence that anticardiolipin antibodies are independent risk factors for atherosclerotic vascular disease

CJ Glueck, JE Lang, T Tracy, L Sieve-Smith… - American Journal of …, 1999 - ajconline.org
Anticardiolipin antibodies (ACLAs) and the lupus anticoagulant (antiphospholipid
antibodies) are risk factors for arterial atherothrombosis and for arterial and venous …

Natural antibodies against phosphorylcholine as potential protective factors in SLE

J Su, X Hua, H Concha, E Svenungsson… - …, 2008 - academic.oup.com
Objective. We have recently reported that natural antibodies against phosphorylcholine (anti-
PC) have atheroprotective properties. Here we compare anti-PC with other autoantibodies in …