Viruses use the host cellular machinery to translate viral proteins. Similar to cellular proteins
directed to the secretory pathway, viral (glyco) proteins are synthesized on polyribosomes …

Abstract A series of M2/NB chimeras were used to investigate the ion channel activity of the
IAV M2 protein. Replacing the M2 cytoplasmic domain with the equivalent NB domain (AAB …

Eukaryotic cells have evolved a myriad of ion channels, transporters, and pumps to maintain
and regulate transmembrane ion gradients. As intracellular parasites, viruses also have …

Viruses are infectious units with diameters of about 16 nm (circoviruses) to over 300 nm
(poxviruses; Table 2.1). Their small size makes them ultrafilterable, ie they are not retained …

Recent outbreaks of highly pathogenic avian influenza A virus infections (H5 and H7
subtypes) in poultry and humans have raised concerns that a new influenza pandemic will …

The amantadine-sensitive ion channel activity of influenza A virus M2 protein was
discovered through understanding the two steps in the virus life cycle that are inhibited by …

The structure of Mengo encephalomyelitis virus was refined at 3 Å resolution with a final R-
factor of 0.221 and a root-mean-square deviation from idealized bond lengths of 0.019 Å for …

Picornaviruses are associated with acute and chronic diseases. The clinical manifestations
of infections are often mild, but infections may also lead to respiratory symptoms …

Many viral genomes encode small, integral membrane proteins that form homo-oligomeric
channels in membrane, and they transport protons, cations, and other molecules across the …

Viroporins compose a group of small hydrophobic transmembrane proteins that can form
hydrophilic pores through lipid bilayers. Viroporins have been implicated in promoting virus …