Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery

H Lomas, M Massignani, KA Abdullah, I Canton… - Faraday …, 2008 - pubs.rsc.org
We have recently achieved efficient cytosolic delivery by using pH-sensitive poly (2-
(methacryloyloxy) ethylphosphorylcholine)-co-poly (2-(diisopropylamino) …

[PDF][PDF] Biomimetic pH sensitive polymersomes for efficient DNA encapsulation and delivery

H Lomas, I Canton, S MacNeil, J Du, SP Armes… - Advanced …, 2007 - academia.edu
Recently, the ability of natural phospholipids to self-assemble into organized membrane-
enclosed structures has been mimicked by amphiphilic copolymers.[1, 2] These synthetic …

Efficient Encapsulation of Plasmid DNA in pH‐Sensitive PMPC–PDPA Polymersomes: Study of the Effect of PDPA Block Length on Copolymer–DNA Binding Affinity

H Lomas, J Du, I Canton, J Madsen… - Macromolecular …, 2010 - Wiley Online Library
We report the self‐assembly of a series of amphiphilic diblock copolymers comprising a
biocompatible, hydrophilic block, poly (2‐methacryloyloxyethyl phosphorylcholine)(PMPC) …

Fully synthetic polymer vesicles for intracellular delivery of antibodies in live cells

I Canton, M Massignani, N Patikarnmonthon… - The FASEB …, 2013 - Wiley Online Library
There is an emerging need both in pharmacology and within the biomedical industry to
develop new tools to target intracellular mechanisms. The efficient delivery of functionally …

Synthesis and characterization of reactive PEO–PMCL polymersomes

MA Petersen, L Yin, E Kokkoli, MA Hillmyer - Polymer Chemistry, 2010 - pubs.rsc.org
Targeted drug delivery offers the possibility to greatly improve treatment outcomes for
diseases such as cancer by enhancing specificity, thus minimizing detrimental side effects …

Microfluidic-assisted engineering of quasi-monodisperse pH-responsive polymersomes toward advanced platforms for the intracellular delivery of hydrophilic …

LJC Albuquerque, V Sincari, A Ja? ger, R Konefa?… - Langmuir, 2019 - ACS Publications
The extracellular and subcellular compartments are characterized by specific pH levels that
can be modified by pathophysiological states. This scenario encourages the use of …

pH-sensitive block copolymer vesicles with variable trigger points for drug delivery

J Du, L Fan, Q Liu - Macromolecules, 2012 - ACS Publications
We have previously reported the preparation of a novel pH-sensitive and biocompatible
polymer vesicle in pure water based on the spontaneous self-assembly of a diblock …

Multicompartmentalized polymersomes for selective encapsulation of biomacromolecules

Z Fu, MA Ochsner, HPM de Hoog, N Tomczak… - Chemical …, 2011 - pubs.rsc.org
Multicompartmentalized polymersomes are formed using block co-polymers PMOXA–PDMS–
PMOXA and PS-PIAT, and are subsequently proven to be capable of selective …

Polymersome production on a microfluidic platform using pH sensitive block copolymers

L Brown, SL McArthur, PC Wright, A Lewis, G Battaglia - Lab on a Chip, 2010 - pubs.rsc.org
Development of pH sensitive biocompatible block copolymer polymersomes, which are
stable in physiological conditions, is enabling the intracellular delivery of water soluble …

Polymersome‐loaded capsules for controlled release of DNA

H Lomas, APR Johnston, GK Such, Z Zhu, K Liang… - Small, 2011 - Wiley Online Library
The formation of a novel drug‐delivery carrier for the controlled release of plasmid DNA that
comprises layer‐by‐layer polymer capsules subcompartmentalized with pH‐sensitive …