Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery
H Lomas, M Massignani, KA Abdullah, I Canton… - Faraday …, 2008 - pubs.rsc.org
We have recently achieved efficient cytosolic delivery by using pH-sensitive poly (2-
(methacryloyloxy) ethylphosphorylcholine)-co-poly (2-(diisopropylamino) …
(methacryloyloxy) ethylphosphorylcholine)-co-poly (2-(diisopropylamino) …
[PDF][PDF] Biomimetic pH sensitive polymersomes for efficient DNA encapsulation and delivery
Recently, the ability of natural phospholipids to self-assemble into organized membrane-
enclosed structures has been mimicked by amphiphilic copolymers.[1, 2] These synthetic …
enclosed structures has been mimicked by amphiphilic copolymers.[1, 2] These synthetic …
Efficient Encapsulation of Plasmid DNA in pH‐Sensitive PMPC–PDPA Polymersomes: Study of the Effect of PDPA Block Length on Copolymer–DNA Binding Affinity
We report the self‐assembly of a series of amphiphilic diblock copolymers comprising a
biocompatible, hydrophilic block, poly (2‐methacryloyloxyethyl phosphorylcholine)(PMPC) …
biocompatible, hydrophilic block, poly (2‐methacryloyloxyethyl phosphorylcholine)(PMPC) …
Fully synthetic polymer vesicles for intracellular delivery of antibodies in live cells
I Canton, M Massignani, N Patikarnmonthon… - The FASEB …, 2013 - Wiley Online Library
There is an emerging need both in pharmacology and within the biomedical industry to
develop new tools to target intracellular mechanisms. The efficient delivery of functionally …
develop new tools to target intracellular mechanisms. The efficient delivery of functionally …
Synthesis and characterization of reactive PEO–PMCL polymersomes
Targeted drug delivery offers the possibility to greatly improve treatment outcomes for
diseases such as cancer by enhancing specificity, thus minimizing detrimental side effects …
diseases such as cancer by enhancing specificity, thus minimizing detrimental side effects …
Microfluidic-assisted engineering of quasi-monodisperse pH-responsive polymersomes toward advanced platforms for the intracellular delivery of hydrophilic …
LJC Albuquerque, V Sincari, A Ja? ger, R Konefa?… - Langmuir, 2019 - ACS Publications
The extracellular and subcellular compartments are characterized by specific pH levels that
can be modified by pathophysiological states. This scenario encourages the use of …
can be modified by pathophysiological states. This scenario encourages the use of …
pH-sensitive block copolymer vesicles with variable trigger points for drug delivery
J Du, L Fan, Q Liu - Macromolecules, 2012 - ACS Publications
We have previously reported the preparation of a novel pH-sensitive and biocompatible
polymer vesicle in pure water based on the spontaneous self-assembly of a diblock …
polymer vesicle in pure water based on the spontaneous self-assembly of a diblock …
Multicompartmentalized polymersomes for selective encapsulation of biomacromolecules
Z Fu, MA Ochsner, HPM de Hoog, N Tomczak… - Chemical …, 2011 - pubs.rsc.org
Multicompartmentalized polymersomes are formed using block co-polymers PMOXA–PDMS–
PMOXA and PS-PIAT, and are subsequently proven to be capable of selective …
PMOXA and PS-PIAT, and are subsequently proven to be capable of selective …
Polymersome production on a microfluidic platform using pH sensitive block copolymers
Development of pH sensitive biocompatible block copolymer polymersomes, which are
stable in physiological conditions, is enabling the intracellular delivery of water soluble …
stable in physiological conditions, is enabling the intracellular delivery of water soluble …
Polymersome‐loaded capsules for controlled release of DNA
The formation of a novel drug‐delivery carrier for the controlled release of plasmid DNA that
comprises layer‐by‐layer polymer capsules subcompartmentalized with pH‐sensitive …
comprises layer‐by‐layer polymer capsules subcompartmentalized with pH‐sensitive …