Epigenetics processes may play a vital role in the biological embedding of early
environmental adversity and the development of psychopathology. Accumulating evidence …

Early childhood experiences have lasting effects on development, including the risk for
psychiatric disorders. Research examining the biologic underpinnings of these associations …

The present study examined the effect of early life stress (ELS) on the glucocorticoid
receptor gene (NR3C1) methylation, the associations between NR3C1 methylation and …

Accumulating evidence suggests that early adversity is linked to methylation of the
glucocorticoid receptor (GR) gene, NR3C1, which is a key regulator of the hypothalamic …

Stress early in life is a known risk factor for the development of affective disorders later in life.
Epigenetic mechanisms, such as DNA methylation, may have an important role in mediating …

Epigenetic modifications to the genome are a key mechanism involved in the biological
encoding of experience. Animal studies and a growing body of literature in humans have …

Background A history of early adverse experiences is an important risk factor for adult
psychopathology. Changes in stress sensitivity and functioning of the hypothalamic-pituitary …

Children exposed to extreme stress are at heightened risk for developing mental and
physical disorders. However, little is known about mechanisms underlying these …

Early adversity increases risk for developing psychopathology. Epigenetic modification of
stress reactivity genes is a likely mechanism contributing to this risk. The glucocorticoid …

Early life adversity and psychopathology are thought to be linked through HPA-axis
deregulation. Changes in methylation levels of stress reactivity genes such as the …