Purpose: To study the effect of two tidal volumes on gas exchange, lung mechanics, and
hemodynamics in 12 patients with acute respiratory distress syndrome (ARDS) within the …

Objective To assess the effect of changes in tidal volume (VT) with a constant inspiratory
flow and minute ventilation (̇ V_E) on gas exchange and oxygen transport in acute …

Objective: To assess the effects of step-changes in tidal volume on work of breathing during
lung-protective ventilation in patients with acute lung injury (ALI) or the acute respiratory …

Rationale: Tidal volume and plateau pressure limitation decreases mortality in acute
respiratory distress syndrome. Computed tomography demonstrated a small, normally …

Objective: Acute respiratory distress syndrome is characterized by collapse of gravitationally
dependent lung regions that usually diverts tidal ventilation toward nondependent regions …

Objective: To determine the usual practice for setting tidal volume and other ventilatory
parameters in patients with acute respiratory distress syndrome (ARDS) in the late 1990s …

Background Use of a low tidal volume (VT) strategy in the treatment of acute respiratory
distress syndrome can lead to a decrease in oxygenation. This study evaluated the safety …

Background Traditional approaches to mechanical ventilation use tidal volumes of 10 to 15
ml per kilogram of body weight and may cause stretch-induced lung injury in patients with …

Objective: To examine the effects of mechanical ventilation with a tidal volume of 6 mL/kg
compared with 12 mL/kg predicted body weight on hemodynamics, vasopressor use, fluid …

Objectives: A recent randomized trial of mechanical ventilation in acute lung injury
(ALI)/adult respiratory distress syndrome (ARDS) demonstrated a 22% relative reduction in …