The toxic alkaloid nicotine is produced in the roots of Nicotiana species and primarily
accumulates in leaves as a specialized metabolite. A series of metabolic and transport …

Tobacco alkaloid metabolism is regulated by various transcription factors (TFs). Here, we
have characterized a non-NIC2 locus gene, Ethylene Response Factor 91 (ERF91), function …

Nicotine biosynthesis in tobacco (Nicotiana tabacum L.) is highly regulated by jasmonic acid
(JA). Two nuclear loci, A and B (renamed NIC1 and NIC2) have been identified that mediate …

Tobacco (Nicotiana tabacum) synthesizes nicotine and related pyridine alkaloids in the root,
and their synthesis increases upon herbivory on the leaf via a jasmonate-mediated signaling …

Nicotine and tropane alkaloids are specialized metabolites produced in certain species of
Solanaceae, and some of these alkaloids have been used as pharmacological agents. In …

Nicotine, the most abundant pyridine alkaloid in cultivated tobacco (Nicotiana tabacum L.), is
a potent inhibitor of insect and animal herbivory and a neurostimulator of human brain …

Gene duplication is a powerful source of phenotypic diversity in plants, but the molecular
mechanisms that generate new functions in duplicated genes are not fully documented …

In tobacco (Nicotiana tabacum), several transcription factors belonging to the IXa group of
APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) cluster at the regulatory NIC2 …

The down-regulation of a tobacco (Nicotiana tabacum) plasma membrane-localized nicotine
uptake permease, NUP1, was previously reported to reduce total alkaloid levels in tobacco …

In tobacco, the homologous ETHYLENE RESPONSE FACTOR (ERF) transcription factors
ERF199 and ERF189 coordinate the transcription of multiple metabolic genes involved in …