Our goal was to examine whether exercise training (ExT) could normalize impaired nitric
oxide synthase (NOS)-dependent dilation of cerebral (pial) arterioles during type 1 diabetes …

Background and Purpose—Our goal was to identify the effects of chronic treatment with
enalapril on cerebrovascular dysfunction and endothelial nitric oxide synthase (eNOS) …

Aim/hypothesis Postpandrial hyperglycaemia is a significant risk factor for the development
of macrovascular diseases. There is no clear agreement in the field whether these …

Diabetes mellitus is the most common cause of neuropathy which is estimated to affect 20-
30 million people worldwide [1]. Clinical trials in subjects with Type 1 and Type 2 diabetes …

We hypothesize that poly (ADP-ribose) polymerase (PARP) activation is an important
mechanism in the oxidative stress-related development of diabetic retinopathy. In the …

Background—We have previously shown that endothelial function is impaired not only in
diabetes but also in subjects at risk of developing type 2 diabetes. We hypothesized that …

The goal of this study was to test the hypothesis that administration of superoxide dismutase
restores nitric oxide synthase-mediated dilatation of the basilar artery during diabetes …

Evidence that poly (ADP-ribose) polymerase (PARP) activation plays an important role in
diabetic complications is emerging. This study evaluated the role of PARP in rat and mouse …

Complications of diabetes rather than the primary disease itself pose the most challenging
aspects of diabetic patient management. Diabetic vascular dysfunction represents a problem …

Peripheral diabetic neuropathy is a heterogeneous group of disorders, and is known to
affect 50–60% of diabetic patients. Poly (ADP-ribose) polymerase (PARP) activation has …