Glycemic control is the primary mediator of diabetic microvascular complications and also
contributes to macrovascular complications. A new study (see related article beginning on …

Please cite this paper as: Arrick and Mayhan (2010). Inhibition of Endothelin‐1 Receptors
Improves Impaired Nitric Oxide Synthase‐Dependent Dilation of Cerebral Arterioles in Type …

ADP mediates platelet-induced relaxation of blood vessels and may function as an important
intercellular signaling molecule in the brain. We used pharmacological and genetic …

Hyperglycemia-induced overproduction of superoxide by mitochondrial electron-transport
chain triggers several pathways of injury involved in the pathogenesis of diabetic …

Our goals were to determine both the effects of chronic insulin treatment on the impaired
endothelium-dependent relaxation present in basilar arteries from established diabetic rats …

The objective of the present study was to examine the role of the angiotensin II type 1
receptor (AT1-R) in the diabetes-aggravated oxidative stress and brain injury observed in a …

Background and purpose: Diabetes mellitus (DM) is a major stroke risk factor and is
associated with poor recovery compared with nondiabetic stroke patients. In the present …

We examined the responses of basilar arteries taken from Otsuka Long-Evans Tokushima
Fatty (OLETF) rats, a type 2 diabetes model. Both the nitric oxide (NO)-mediated relaxation …

ia-inducible factor-1α (Figure). 25, 26 Although relatively little is known regarding effects of
ROS on gene expression in vascular cells, examples of such effects are beginning to …

Diabetic neuropathy is the most common diabetic complication. The pathogenetic pathways
include oxidative stress, advanced glycation end product (AGE) formation, protein kinase C …