Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic
cellular screening, allowing millions of compounds to be assayed and delivering clinical …

Highlights•The antimalarial pipeline has been enriched with new molecules and
targets.•The antimalarial target compound and product profiles have been redefined.•In …

Malaria elimination has recently been reinstated as a global health priority but current
therapies seem to be insufficient for the task. Elimination efforts require new drug classes …

Despite substantial scientific progress over the past two decades, malaria remains a
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …

Antimalarial drugs have played a mainstream role in controlling the spread of malaria
through the treatment of patients infected with the plasmodial parasites and controlling its …

Malaria is still considered a deadly scourge in Africa, Asia, and South America despite
improved vector control and curative treatments with new antimalarial combinations. The …

Though morbidity and mortality due to malaria have declined in the last 15 years, emerging
resistance to first-line artemisinin-based antimalarials, absence of efficacious vaccines and …

For reprint orders, please contact reprints@ future-science. com parasites in multi-well
plates and screen in highthroughput modes based, typically, on metabolic or proliferation …

Major advances in our understanding of malaria parasite biology have been made. Coupled
with the completion of the malaria genome, this has presented exciting opportunities for …

In recent years, the research agenda to tackle global morbidity and mortality from malaria
disease has shifted towards innovation, in the hope that efforts at the frontiers of scientific …