Mitochondria are considered major regulators of longevity, although their exact role in aging
is not fully understood. Data from different laboratories show a negative correlation between …

The role of mitochondrial complex I in aging has been studied in both C. elegans and
Drosophila, where RNAi knock down of specific complex I subunits has been shown to …

This review focuses on some of the 'hot topics' that fall under the general heading
'mitochondria and aging'. For each selected topic, we highlight recent publications that have …

Since the initial identification of reactive oxygen species (ROS) as the major factor in aging,
many studies have provided evidence for the central role of mitochondria in longevity. A few …

In mammals during aging, reactive oxygen species (ROS), produced by the mitochondrial
respiratory chain, cause oxidative damage of macromolecules leading to respiratory chain …

The sirtuins are a family of proteins that act predominantly as nicotinamide adenine
dinucleotide (NAD)-dependent deacetylases. In mammals seven sirtuin family members …

The nuo-6 and isp-1 genes of C. elegans encode, respectively, subunits of complex I and III
of the mitochondrial respiratory chain. Partial loss-of-function mutations in these genes …

Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

Understanding how alterations in mitochondrial function in different cells and tissues
impacts the aging process remains one of the greatest challenges facing biogerontologists …

Mitochondrial function is an important determinant of the ageing process; however, the
mitochondrial properties that enable longevity are not well understood. Here we show that …