Bone formation and development is a dynamic process involving a series of precisely
controlled, distinct, cellular, and biochemical events. As bone matures, stage-specific bone …

The skeleton is essentially responsible for not only providing structural support and
protection to the body's organs but also serving as a reservoir for calcium, magnesium, and …

Bone formation and development is a dynamic process involving a series of precisely
controlled, distinct, cellular and biochemical events. As bone matures, stage-specific …

The development of bone is a complex process that involves cellular, extracellular, and
physicochemical events. Here, the overall process of bone formation is reviewed from a …

The organic matrix of bone contains several protein families, including collagens,
proteoglycans, and glycoproteins, all of which may be extensively modified by …

At the end of many meetings on calcified tissue, I often walk away with the impression that
mineralized matrix is largely considered a massive, inert ''support''for bone cells. In other …

Bone represents the largest proportion of the connective tissues in the human body where it
functions in the protection of internal organs, as a framework for muscle attachment to …

In the last 20 years, researchers have identified a number of matrix proteins and
proteoglycans that may play a role in skeletal dynamics. Early studies focused on these …

Structural hierarchies are common in biologic systems and are particularly evident in
biomineralized structures. In the craniofacial complex and skeleton of vertebrates …

Mineral-matrix interactions regulate the process of hydroxyapatite formation in bones and
teeth. In mineralizing tissues, many anionic macromolecules bind to mineral. By means of …