Cell competition in vertebrates—A key machinery for tissue homeostasis

T Maruyama, Y Fujita - Current Opinion in Genetics & Development, 2022 - Elsevier
Cell competition is a process by which cells with different properties compete with each
other for survival and space, and consequently suboptimal/abnormal cells are often …

Cell competition in development: information from flies and vertebrates

E Madan, R Gogna, E Moreno - Current opinion in cell biology, 2018 - Elsevier
Cell competition is a biological mechanism conserved from Drosophila to vertebrates
wherein neighboring cells compare their relative fitness status resulting in the elimination of …

Cell competition: mechanisms and physiological roles

C Clavería, M Torres - Annual review of cell and developmental …, 2016 - annualreviews.org
Cell-competitive interactions are widespread in nature and determine the outcome of a vast
variety of biological processes. A particular class of competitive interactions takes place …

Picking winners and losers: cell competition in tissue development and homeostasis

W Kim, R Jain - Trends in Genetics, 2020 - cell.com
Viable cells with reduced fitness are often eliminated by neighboring cells with greater
fitness. This phenomenon, called cell competition, is an important mechanism for …

[HTML][HTML] Cell competition: A historical perspective

G Morata - Developmental Biology, 2021 - Elsevier
Cell competition is a homeostatic process designed to remove from animal tissues viable
cells that are unfit, abnormal or malignant and that may compromise the general fitness or …

EDAC: Epithelial defence against cancer—cell competition between normal and transformed epithelial cells in mammals

M Kajita, Y Fujita - The journal of biochemistry, 2015 - academic.oup.com
During embryonic development or under certain pathological conditions, viable but
suboptimal cells are often eliminated from the cellular society through a process termed cell …

Cell competition during growth and regeneration

R Gogna, K Shee, E Moreno - Annual review of genetics, 2015 - annualreviews.org
Tissue growth and regeneration are autonomous, stem-cell-mediated processes in which
stem cells within the organ self-renew and differentiate to create new cells, leading to new …

Physiological and pathological relevance of cell competition in fly to mammals

S Kon - Development, Growth & Differentiation, 2018 - Wiley Online Library
In multicellular organisms, incidentally emerging suboptimal cells are removed to maintain
homeostasis of tissues. The unfavorable cells are excluded by a process termed cell …

Cell wars: regulation of cell survival and proliferation by cell competition

S Vivarelli, L Wagstaff, E Piddini - Essays in biochemistry, 2012 - portlandpress.com
During cell competition fitter cells take over the tissue at the expense of viable, but less fit,
cells, which are eliminated by induction of apoptosis or senescence. This probably acts as a …

New frontiers in cell competition

S de Beco, M Ziosi, LA Johnston - Developmental dynamics, 2012 - Wiley Online Library
Cellular communication is at the heart of animal development, and guides the specification
of cell fates, the movement of cells within and between tissues, and the coordinated …