Oral phosphodiesterase type 5 inhibitors: nonerectogenic beneficial uses

T Mostafa - The journal of sexual medicine, 2008 - academic.oup.com
ABSTRACT Introduction Phosphodiesterase type 5 (PDE5) hydrolyses cyclic guanylate
monophosphate (cGMP) specifically to 5′ GMP. PDE5 inhibitors were a breakthrough …

Useful implications of low-dose long-term use of PDE-5 inhibitors

T Mostafa - Sexual Medicine Reviews, 2016 - academic.oup.com
Abstract Introduction Phosphodiesterase type 5 (PDE-5) hydrolyzes cyclic guanylate
monophosphate (cGMP) specifically to 5′ GMP, promoting successful corporeal vascular …

PDE5 inhibitors in non-urological conditions

C Vlachopoulos, D Terentes-Printzios… - Current …, 2009 - ingentaconnect.com
Phosphodiesterase type-5 (PDE5) inhibitors are widely used as first-line therapy for erectile
dysfunction (ED). Their efficacy and safety combined with an increasing understanding of …

Non-sexual implications of phosphodiesterase type 5 inhibitors

T Mostafa - Sexual Medicine Reviews, 2017 - academic.oup.com
Abstract Introduction Phosphodiesterase type 5 (PDE5) hydrolyses cyclic guanylate
monophosphate specifically to 5′ guanylate monophosphate, promoting corporeal …

Investigational noncardiovascular uses of phosphodiesterase-5 inhibitors

RA Kloner, G Comstock, LA Levine, S Tiger… - Expert Opinion on …, 2011 - Taylor & Francis
Introduction: At the present time, inhibitors of phosphodiesterase type 5 (PDE5) have Food
and Drug Administration approval only for the treatment of erectile dysfunction and …

The effects of chronic phosphodiesterase-5 inhibitor use on different organ systems

ER Schwarz, V Kapur, J Rodriguez, S Rastogi… - International journal of …, 2007 - nature.com
Abstract Phosphodiesterase-5 (PDE-5) inhibitors selectively inhibit PDE-5 enzymes that are
present in various tissues like penile tissue, platelets, vascular, and smooth muscle tissue …

PDE5 inhibitors beyond erectile dysfunction

P Sandner, J Hütter, H Tinel, K Ziegelbauer… - International journal of …, 2007 - nature.com
Abstract The phosphodiesterase type-5 (PDE5) inhibitors sildenafil, vardenafil and tadalafil
are widely used first-line therapy for erectile dysfunction (ED). Since the advent of sildenafil …

Phosphodiesterase type 5 inhibitors: unmet needs

K Hatzimouratidis… - Current pharmaceutical …, 2009 - ingentaconnect.com
Erectile dysfunction (ED) has been revolutionized during the last two decades, as several
treatment options are available today. Phosphodiesterase type 5 (PDE5) inhibitors …

Cardiovascular effects of phosphodiesterase type 5 inhibitors

C Vlachopoulos, N Ioakeimidis… - The Journal of …, 2009 - academic.oup.com
ABSTRACT Introduction Phosphodiesterase type 5 (PDE5) inhibitors are widely used as first-
line therapy for erectile dysfunction (ED). Their efficacy and safety combined with an …

Phosphodiesterase 5 inhibitors and erectile dysfunction

P Sandner, N Svenstrup, H Tinel… - Expert Opinion on …, 2008 - Taylor & Francis
Background: The introduction of phosphodiesterase 5 (PDE5) inhibitors for the treatment of
erectile dysfunction was a landmark in the therapy of this highly prevalent male disorder …