Molecular insights in atrial fibrillation pathogenesis and therapeutics: a narrative review

KA Papathanasiou, SG Giotaki, DA Vrachatis, G Siasos… - Diagnostics, 2021 - mdpi.com
The prevalence of atrial fibrillation (AF) is bound to increase globally in the following years,
affecting the quality of life of millions of people, increasing mortality and morbidity, and …

Novel mechanisms in the pathogenesis of atrial fibrillation: practical applications

DH Lau, U Schotten, R Mahajan, NA Antic… - European heart …, 2016 - academic.oup.com
Intensive research over the last few decades has seen significant advances in our
understanding of the complex mechanisms underlying atrial fibrillation (AF). The epidemic of …

Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

Electrical remodeling in atrial fibrillation

D Dobrev - Herz, 2006 - search.proquest.com
Electrical remodeling refers to any change in electrical function that promotes atrial
fibrillation (AF). A key advance in understanding the mechanisms of AF has been the …

Comprehensive evaluation of electrophysiological and 3D structural features of human atrial myocardium with insights on atrial fibrillation maintenance mechanisms

AV Mikhailov, A Kalyanasundaram, N Li… - Journal of molecular and …, 2021 - Elsevier
Atrial fibrillation (AF) occurrence and maintenance is associated with progressive
remodeling of electrophysiological (repolarization and conduction) and 3D structural …

Obesity and atrial fibrillation

HS Abed, GA Wittert - Obesity Reviews, 2013 - Wiley Online Library
Atrial fibrillation (AF) is an increasing public health problem, often described as the epidemic
of the new millennium. The rising health economic impact of AF, its association with poor …

[HTML][HTML] Arrhythmogenic substrates for atrial fibrillation in obesity

ER Lubbers, MV Price, PJ Mohler - Frontiers in physiology, 2018 - frontiersin.org
Global obesity rates have nearly tripled since 1975. This obesity rate increase is mirrored by
increases in atrial fibrillation (AF) that now impacts nearly 10% of Americans over the age of …

[HTML][HTML] Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation

R Pathak, DH Lau, R Mahajan… - Journal of atrial …, 2013 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most commonly encountered arrhythmia in clinical practice.
Despite advances in our understanding of the pathophysiology of this complex arrhythmia …

[HTML][HTML] Atrial fibrillation: mechanisms, therapeutics, and future directions

J Pellman, F Sheikh - Comprehensive Physiology, 2015 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, affecting 1% to 2% of the
general population. It is characterized by rapid and disorganized atrial activation leading to …

Pathophysiological insights into atrial fibrillation: revisiting the electrophysiological substrate, anatomical substrate, and possible insights from proteomics

R Bentley, SJRJ Logantha, P Sharma… - Cardiovascular …, 2021 - academic.oup.com
Atrial fibrillation (AF) is the most common supraventricular arrhythmia. In AF, the irregular
cardiac rhythm is associated with intra-atrial blood stasis, subsequent thrombus formation …