FOXP transcription factors in vertebrate brain development, function, and disorders

M Co, AG Anderson, G Konopka - Wiley Interdisciplinary …, 2020 - Wiley Online Library
FOXP transcription factors are an evolutionarily ancient protein subfamily coordinating the
development of several organ systems in the vertebrate body. Association of their genes …

Understanding language from a genomic perspective

SA Graham, SE Fisher - Annual review of genetics, 2015 - annualreviews.org
Language is a defining characteristic of the human species, but its foundations remain
mysterious. Heritable disorders offer a gateway into biological underpinnings, as illustrated …

Small intragenic deletion in FOXP2 associated with childhood apraxia of speech and dysarthria

SJ Turner, MS Hildebrand, S Block… - American journal of …, 2013 - Wiley Online Library
Relatively little is known about the neurobiological basis of speech disorders although
genetic determinants are increasingly recognized. The first gene for primary speech disorder …

FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis

RJ Kast, AL Lanjewar, CD Smith, P Levitt - Elife, 2019 - elifesciences.org
The expression patterns of the transcription factor FOXP2 in the developing mammalian
forebrain have been described, and some studies have tested the role of this protein in the …

Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons

HY Kuo, SY Chen, RC Huang, H Takahashi, YH Lee… - Brain, 2023 - academic.oup.com
Human speech and language are among the most complex motor and cognitive abilities.
The discovery of a mutation in the transcription factor FOXP2 in KE family members with …

Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia

SC Vernes, KD MacDermot, AP Monaco… - European Journal of …, 2009 - nature.com
Neurodevelopmental disorders that disturb speech and language are highly heritable.
Isolation of the underlying genetic risk factors has been hampered by complexity of the …

Molecular genetics of speech and language disorders

DF Newbury, AP Monaco - Current opinion in pediatrics, 2002 - journals.lww.com
In 2001, scientists characterized the first gene to be implicated in the cause of a speech and
language disorder (FOXP2). Although FOXP2 was discovered using a unique family in …

FoxP2 regulates neurogenesis during embryonic cortical development

D Tsui, JP Vessey, H Tomita, DR Kaplan… - Journal of …, 2013 - Soc Neuroscience
The transcription factor FoxP2 has been associated with the development of human speech
but the underlying cellular function of FoxP2 is still unclear. Here we provide evidence that …

Genetic components of vocal learning

C Scharff, SA White - Annals of the New York Academy of …, 2004 - Wiley Online Library
Vocal learning is a rare trait. Humans depend on vocal learning to acquire spoken
language, but most species that communicate acoustically have an innate repertoire of …

FoxP2 regulation during undirected singing in adult songbirds

I Teramitsu, SA White - Journal of Neuroscience, 2006 - Soc Neuroscience
Learned vocal communication, including human speech, is a socially influenced behavior
limited to certain animals. This ability requires auditory feedback during vocalization, which …