Breaking and joining single-stranded DNA: the HUH endonuclease superfamily
HUH endonucleases are numerous and widespread in all three domains of life. The major
function of these enzymes is processing a range of mobile genetic elements by catalysing …
function of these enzymes is processing a range of mobile genetic elements by catalysing …
Crystal structure and functional implications of Pyrococcus furiosus hef helicase domain involved in branched DNA processing
T Nishino, K Komori, D Tsuchiya, Y Ishino, K Morikawa - Structure, 2005 - cell.com
DNA and RNA frequently form various branched intermediates that are important for the
transmission of genetic information. Helicases play pivotal roles in the processing of these …
transmission of genetic information. Helicases play pivotal roles in the processing of these …
Molecular underpinnings of ssDNA specificity by Rep HUH-endonucleases and implications for HUH-tag multiplexing and engineering
Replication initiator proteins (Reps) from the HUH-endonuclease superfamily process
specific single-stranded DNA (ssDNA) sequences to initiate rolling circle/hairpin replication …
specific single-stranded DNA (ssDNA) sequences to initiate rolling circle/hairpin replication …
The X philes: structure‐specific endonucleases that resolve Holliday junctions
GJ Sharples - Molecular Microbiology, 2001 - Wiley Online Library
Genetic recombination is a critical cellular process that promotes evolutionary diversity,
facilitates DNA repair and underpins genome duplication. It entails the reciprocal exchange …
facilitates DNA repair and underpins genome duplication. It entails the reciprocal exchange …
Holliday junction resolvases
Four-way DNA intermediates, called Holliday junctions (HJs), can form during meiotic and
mitotic recombination, and their removal is crucial for chromosome segregation. A group of …
mitotic recombination, and their removal is crucial for chromosome segregation. A group of …
Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation
The XPD protein is a vital subunit of the general transcription factor TFIIH which is not only
involved in transcription but is also an essential component of the eukaryotic nucleotide …
involved in transcription but is also an essential component of the eukaryotic nucleotide …
Mechanisms of helicase-catalyzed DNA unwinding
TM Lohman, KP Bjornson - Annual review of biochemistry, 1996 - annualreviews.org
DNA helicases are essential motor proteins that function to unwind duplex DNA to yield the
transient single-stranded DNA intermediates required for replication, recombination, and …
transient single-stranded DNA intermediates required for replication, recombination, and …
Polymerase θ-helicase efficiently unwinds DNA and RNA-DNA hybrids
POLQ is a unique multifunctional replication and repair gene that encodes for a N-terminal
superfamily 2 helicase and a C-terminal A-family polymerase. Although the function of the …
superfamily 2 helicase and a C-terminal A-family polymerase. Although the function of the …
[HTML][HTML] Helicase-catalyzed DNA unwinding.
TM Lohman - Journal of Biological Chemistry, 1993 - Elsevier
DNA helicases are ubiquitous and multiple helicases have been identified in a number of
prokaryotes and eukaryotes. Although it is clear that not all helicases function identically …
prokaryotes and eukaryotes. Although it is clear that not all helicases function identically …
Homing endonucleases: from microbial genetic invaders to reagents for targeted DNA modification
BL Stoddard - Structure, 2011 - cell.com
Homing endonucleases are microbial DNA-cleaving enzymes that mobilize their own
reading frames by generating double strand breaks at specific genomic invasion sites …
reading frames by generating double strand breaks at specific genomic invasion sites …