OBJECTIVE Chronic exercise and obesity both increase intramyocellular triglycerides
(IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that …

The inability of insulin to stimulate glucose metabolism in skeletal muscle is a classic
characteristic of type 2 diabetes, but this insulin resistance entails altered patterns of lipid …

Obesity predisposes individuals to the development of insulin resistance, which is a risk
factor for type 2 diabetes, and muscle plays a central role in this phenomenon. Insulin …

The term lipotoxicity elicits visions of steatotic liver, fat laden skeletal muscles and engorged
lipid droplets that spawn a number of potentially harmful intermediates that can wreak havoc …

The alarming increase in obesity and associated type 2 diabetes mellitus (T2DM) is a
paramount public health concern in developing countries. Skeletal muscle insulin resistance …

Aims/hypothesis Intramyocellular lipids, including diacylglycerol (DAG) and ceramides, have
been linked to insulin resistance. This randomised repeated-measures study examined the …

BACKGROUND. Accumulation of diacylglycerol (DAG) and sphingolipids is thought to
promote skeletal muscle insulin resistance by altering cellular signaling specific to their …

An alarming increase in the prevalence of obesity, type 2 diabetes mellitus, and associated
diseases can be observed world-wide during the past 20 years. In obesity, profound …

Mounting evidence indicates that elevated intramyocellular triacylglycerol concentrations
are associated with diminished insulin sensitivity in skeletal muscle. This lipid accumulation …

Failure of insulin to elicit an increase in glucose uptake and metabolism in target tissues
such as skeletal muscle is a major characteristic of non-insulin dependent type 2 diabetes …