It is now well accepted that the mechanisms induced by low-dose exposures to ionizing
radiation (LDR) are different from those occurring after high-dose exposures. However, the …

Not-targeted effects represent a paradigm shift from the “DNA centric” view that ionizing
radiation only elicits biological effects and subsequent health consequences as a result of …

The last 20 years have seen a major paradigm shift in radiation biology. Several discoveries
challenge the DNA centric view which holds that DNA damage is the critical effect of …

Recent advances in our understanding of the mechanisms underlying the biological effects
of low dose effects of ionizing radiation have revealed that similar mechanisms can be …

Quantitative mechanistic modeling of the biological effects of ionizing radiation has a long
rich history. Initially, it was dominated by target theory, which quantifies damage caused by …

Exposure of cells to any form of ionizing radiation (IR) is expected to induce a variety of DNA
lesions, including double strand breaks (DSBs), single strand breaks (SSBs) and oxidized …

When people discuss the risks associated with low doses of ionizing radiation, central to the
discussion is the definition of a low dose and the nature of harm. Standard answers such as …

The question whether low doses and low dose-rates of ionizing radiation pose a health risk
to people is of public, scientific and regulatory concern. It is a subject of intense debate and …

Recent insights into the mechanisms underlying the biological effects of low dose effects of
ionising radiation have revealed that similar mechanisms can be induced by chemical …

Radiation risks at low doses remain a hotly debated topic. Recent experimental advances in
our understanding of effects occurring in the progeny of irradiated cells, and/or the non …