Molecules labeled in green and blue play positive and negative roles in Wnt/β-catenin
signaling, respectively. Molecules that are labeled in both colors have dual roles.(Top left) …

Canonical Wnt/β-catenin signaling has central roles in development and diseases, and is
initiated by the action of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein …

Summary β-catenin-mediated Wnt signaling is critical in animal development and tumor
progression. The single-span transmembrane Wnt receptor, low-density lipoprotein receptor …

In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin,
which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and …

The Wnt signaling pathway is a highly conserved regulator of metazoan development and
stem cell maintenance. Activation of Wnt signaling is an early step in diverse malignancies …

Figure 1. Wnt secretion. Wnt is palmitoylated by the Porc acyltransferase, which may
facilitate its exit from the ER. In the trans-Golgi, Wls directs Wnt to the cell surface where it …

Wnt ligands are involved in diverse signaling pathways that are active during development,
maintenance of tissue homeostasis and in various disease states. While signaling regulated …

Wnts are secreted proteins that are essential for a wide array of developmental and
physiological processes. They signal across the plasma membrane by interacting with …

The Wnts comprise a large class of secreted proteins that control essential developmental
processes such as embryonic patterning, cell growth, migration, and differentiation. In the …

Wnt/β-catenin signaling controls various cell fates in metazoan development and is
misregulated in several cancers and developmental disorders. Binding of a Wnt ligand to its …