Introduction: Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia
associated with the presence of persistent antiphospholipid antibodies (aPL). Owing to …

Antiphospholipid antibodies (aPL) are a cluster of autoantibodies directed against plasma
proteins with affinity for membrane phospholipids. The most frequently tested aPL are lupus …

The presence of anti-phospholipid (aPL) is necessary but not sufficient to induce a
thrombotic event. The “second hit” hypothesis suggested that an additional trigger may be …

This issue of Seminars in Thrombosis & Hemostasis is devoted to antiphospholipid (aPL)
antibodies and the antiphospholipid syndrome (APS). aPL antibodies are well-recognized …

Background Antiphospholipid syndrome (APS) is an acquired hypercoagulable condition
associated with antiphospholipid antibody (aPL) presence. Data on re-thrombosis following …

Thrombotic manifestations of antiphospholipid syndrome are often a therapeutic dilemma
and challenge. Despite our increasing knowledge of this relatively new disease, many …

The presence of antiphospholipid antibodies has been shown to be related to an increased
risk of thrombotic events. In patients with definite antiphospholipid syndrome (APS), that is …

Indefinite anticoagulation remains the mainstay of treatment for thrombotic APS. Despite
advances in diagnostic techniques, it remains difficult to predict thrombotic risk in …

Essentials• The clinical value of IgM antibodies in thrombotic antiphospholipid syndrome
(APS) is debated.• By review of literature, we reconsidered the clinical value of IgM …

Objective To evaluate the clinical outcome after aPL (antiphospholipid antibodies)
disappearance in primary APS patients. Methods From a cohort of 70 patients with primary …