Background Recent studies have demonstrated that synthetic dsRNAs may produce
therapeutic effects in a target-independent manner through stimulation of the toll-like …

Abstract Toll-like receptor 3 (TLR3) is a pattern-recognizing receptor that is involved in
immune signaling and plays a crucial role in survival by being able to recognize various viral …

Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumor.
Studies have demonstrated that the toll‑like receptor 3 (TLR3)/interferon pathway is …

Abstract Toll-like receptor 3 (TLR3) is a member of the Toll-like receptors which recognize
pathogen-associated molecular patterns leading to the activation of the innate immune …

Background Toll-like receptors (TLRs) are key factors in the innate immune system and
initiate the inflammatory response to foreign pathogens such as bacteria, fungi and viruses …

Sorafenib resistance remains a major obstacle for the effective treatment of hepatocellular
carcinoma (HCC), and a number of miRNAs contribute to this resistance. However, the …

Toll-like receptors (TLRs) are key factors in the innate immune system and initiate an
inflammatory response to foreign pathogens, such as bacteria, fungi and viruses. TLR4 …

dsRNA can be detected by pattern recognition receptors, for example, TLR3, MDA‐5,
NLRP3 to induce proinflammatory cytokines responsible for innate/adaptive immunity …

Purpose The purpose of this study is to examine the role of the double-stranded RNA
(dsRNA) activated Toll–interleukin-1 receptor domain-containing adaptor inducing interferon …

The multikinase inhibitor, sorafenib, is a first-line treatment for hepatocellular carcinoma
(HCC), but its limited efficacy, drug resistance and toxicity are a concern. In this study, we …