HTLV-1-mediated dysregulation of the Wnt pathways: roles of Tax and HBZ

G Ma, J Yasunaga, J Fan, S Yanagawa, M Matsuoka - Retrovirology, 2014 - Springer
Human T cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia
(ATL). Dysregulations of cellular signaling pathways have been considered to be important …

HTLV-1 bZIP factor dysregulates the Wnt pathways to support proliferation and migration of adult T-cell leukemia cells

G Ma, J Yasunaga, J Fan, S Yanagawa, M Matsuoka - Oncogene, 2013 - nature.com
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia
(ATL). 1–5 HTLV-1 Tax is an important viral transactivator, and has been thought to have a …

TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax

G Ma, J Yasunaga, H Akari… - Proceedings of the …, 2015 - National Acad Sciences
Human T-cell leukemia virus type 1 (HTLV-1) is a delta-type retrovirus that induces
malignant and inflammatory diseases during its long persistence in vivo. HTLV-1 can infect …

HTLV-1 bZIP factor impairs anti-viral immunity by inducing co-inhibitory molecule, T cell immunoglobulin and ITIM domain (TIGIT)

K Yasuma, J Yasunaga, K Takemoto, K Sugata… - PLoS …, 2016 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) infects CD4+ T cells and induces proliferation
of infected cells in vivo, which leads to the onset of adult T-cell leukemia (ATL) in some …

HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo

Y Satou, J Yasunaga, T Zhao, M Yoshida… - PLoS …, 2011 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) is the causal agent of a neoplastic disease of
CD4+ T cells, adult T-cell leukemia (ATL), and inflammatory diseases including HTLV-1 …

HBZ and its roles in HTLV-1 oncogenesis

T Zhao, M Matsuoka - Frontiers in microbiology, 2012 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus
strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ) …

HTLV-1-mediated epigenetic pathway to adult T-cell leukemia–lymphoma

M Yamagishi, D Fujikawa, T Watanabe… - Frontiers in …, 2018 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1), the first reported human oncogenic retrovirus,
is the etiologic agent of highly aggressive, currently incurable diseases such as adult T-cell …

Human T-Cell Leukemia Virus Type 1 Oncogenesis between Active Expression and Latency: A Possible Source for the Development of Therapeutic Targets

F Marino-Merlo, S Grelli, A Mastino, M Lai… - International Journal of …, 2023 - mdpi.com
The human T-cell leukemia virus type 1 (HTLV-1) is the only known human oncogenic
retrovirus. HTLV-1 can cause a type of cancer called adult T-cell leukemia/lymphoma (ATL) …

HTLV-1-host interactions on the development of adult T cell leukemia/lymphoma: virus and host gene expressions

H Tarokhian, H Rahimi, A Mosavat, A Shirdel… - BMC cancer, 2018 - Springer
Background Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of
HTLV-1-host interactions in infected TCD4+ cells. In this study, the HTLV-1 proviral load …

HTLV-1 alters T cells for viral persistence and transmission

A Tanaka, M Matsuoka - Frontiers in microbiology, 2018 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus to be discovered as a
causative agent of adult T-cell leukemia-lymphoma (ATL) and chronic inflammatory …