[HTML][HTML] Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR−/− mice
HW Wang, PY Liu, N Oyama, Y Rikitake… - The FASEB …, 2008 - ncbi.nlm.nih.gov
Rho kinases (ROCKs) are serine-threonine protein kinases that regulate the actin
cytoskeleton. Recent studies suggest that ROCKs also play an important role in …
cytoskeleton. Recent studies suggest that ROCKs also play an important role in …
Rho-Associated Coiled-Coil-Containing Kinase 2 Deficiency in Bone Marrow–Derived Cells Leads to Increased Cholesterol Efflux and Decreased Atherosclerosis
Q Zhou, Y Mei, T Shoji, X Han, K Kaminski, GT Oh… - Circulation, 2012 - Am Heart Assoc
Background—Macrophages play a central role in the development of atherosclerosis.
However, the signaling pathways that regulate their function are not well understood. The …
However, the signaling pathways that regulate their function are not well understood. The …
[HTML][HTML] ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury
K Noma, Y Rikitake, N Oyama, G Yan… - The Journal of …, 2008 - Am Soc Clin Investig
Although Rho-associated kinase (ROCK) activity has been implicated in cardiovascular
diseases, the tissue-and isoform-specific roles of ROCKs in the vascular response to injury …
diseases, the tissue-and isoform-specific roles of ROCKs in the vascular response to injury …
[HTML][HTML] The function of Rho-associated kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease
S Hartmann, AJ Ridley, S Lutz - Frontiers in pharmacology, 2015 - frontiersin.org
Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …
[HTML][HTML] ROCK2 regulates monocyte migration and cell to cell adhesion in vascular endothelial cells
Y Takeda, K Matoba, D Kawanami, Y Nagai… - International journal of …, 2019 - mdpi.com
The small GTPase Rho and its downstream effector, Rho-kinase (ROCK), regulate various
cellular functions, including organization of the actin cytoskeleton, cell adhesion and …
cellular functions, including organization of the actin cytoskeleton, cell adhesion and …
Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1+/− Haploinsufficient Mice
Y Rikitake, N Oyama, CYC Wang, K Noma, M Satoh… - Circulation, 2005 - Am Heart Assoc
Background—Rho GTPase and its downstream target, Rho-associated kinase (ROCK),
have been implicated in diverse cardiovascular diseases such as cardiac hypertrophy …
have been implicated in diverse cardiovascular diseases such as cardiac hypertrophy …
Physiological role of ROCKs in the cardiovascular system
K Noma, N Oyama, JK Liao - American Journal of …, 2006 - journals.physiology.org
Rho-associated kinases (ROCKs), the immediate downstream targets of RhoA, are
ubiquitously expressed serine-threonine protein kinases that are involved in diverse cellular …
ubiquitously expressed serine-threonine protein kinases that are involved in diverse cellular …
Targeting ROCK signaling in health, malignant and non-malignant diseases
R Shahbazi, B Baradaran, M Khordadmehr, S Safaei… - Immunology letters, 2020 - Elsevier
A Rho-associated coiled-coil kinase (ROCK) is identified as a critical downstream effector of
GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ) …
GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ) …
Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation
SB Haudek, D Gupta, O Dewald… - Cardiovascular …, 2009 - academic.oup.com
Abstract Aims Highly proliferative, CD34+/CD45+ fibroblasts derived from monocytic, blood-
borne precursor cells play a critical role in the development of fibrosis in a murine …
borne precursor cells play a critical role in the development of fibrosis in a murine …
A method for measuring Rho kinase activity in tissues and cells
Abstract The Rho‐associated kinases (ROCKs) can regulate cell shape and function by
modulating the actin cytoskeleton. ROCKs are serine‐threonine protein kinases that can …
modulating the actin cytoskeleton. ROCKs are serine‐threonine protein kinases that can …