The microenvironment of solid tumors is characterized by low pO 2 that is well below
physiological levels. Intratumoral hypoxia is a major factor contributing to cancer …

Hypoxia, defined as a decrease of tissue oxygen levels, represents a fundamental
pathophysiological condition in the microenvironment of solid tumors. Tumor hypoxia is …

Solid tumors possess unique microenvironments that are exposed to chronic hypoxic
conditions, so-called tumor hypoxia. Although more than half a century has passed since it …

Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …

Abstract The hypoxia-inducible factor-1 (HIF-1) is primarily involved in the sensing and
adapting of cells to changes in the O2 level, which is essential for their viability. An …

Hypoxia develops in the majority of solid tumors due to the inability of the existing vascular
system to supply the growing tumor mass with adequate amounts of oxygen. A large body of …

Hypoxia has been recognized as one of the fundamentally important features of solid tumors
and plays a critical role in various cellular and physiologic events, including cell …

Solid tumors often present regions of decreased oxygen levels (hypoxia) due to an
imbalance between increased oxygen consumption and insufficient oxygen delivery from …

Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are
more aggressive and resistant to anti-neoplastic treatments. HIF-1? plays a major role in the …

Hypoxia is a common phenomenon of solid tumors and contributes to aggressive phenotype
and treatment failure. Hypoxia-inducible factor (HIF), a versatile transcription factor that …