Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics
CES1 is involved in the hydrolysis of ester group-containing xenobiotic and endobiotic
compounds including several essential and commonly used drugs. The individual variation …
compounds including several essential and commonly used drugs. The individual variation …
Carboxylesterase 1 and precision pharmacotherapy: pharmacogenetics and nongenetic regulators
Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers,
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80 …
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80 …
Natural products as modulators of CES1 activity
Y Qian, JS Markowitz - Drug Metabolism and Disposition, 2020 - ASPET
Carboxylesterase (CES) 1 is the predominant esterase expressed in the human liver and is
capable of catalyzing the hydrolysis of a wide range of therapeutic agents, toxins, and …
capable of catalyzing the hydrolysis of a wide range of therapeutic agents, toxins, and …
Regulation of carboxylesterases and its impact on pharmacokinetics and pharmacodynamics: an up-to-date review
ABSTRACT Introduction Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
Functional study of carboxylesterase 1 protein isoforms
Abstract Carboxylesterase 1 (CES1) is a primary human hepatic hydrolase involved in
hydrolytic biotransformation of numerous medications. Considerable interindividual …
hydrolytic biotransformation of numerous medications. Considerable interindividual …
Novel procedure with improved resolution and specificity for amplification and differentiation of variants of the gene encoding carboxylesterase 1
D Bjerre, HB Rasmussen… - Pharmacogenetics …, 2017 - journals.lww.com
Abstract Carboxylesterase 1 (CES1) is implicated in the metabolism of several commonly
used drugs and other xenobiotics. The gene encoding this enzyme, CES1, is duplicated in …
used drugs and other xenobiotics. The gene encoding this enzyme, CES1, is duplicated in …
Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus
Objective CES1 encodes carboxylesterase-1, an important drug-metabolizing enzyme with
high expression in the liver. Previous studies have reported a genomic translocation of the …
high expression in the liver. Previous studies have reported a genomic translocation of the …
Carboxylesterase 1 genes: systematic review and evaluation of existing genotyping procedures
HB Rasmussen, MB Madsen… - Drug Metabolism and …, 2018 - degruyter.com
Abstract The carboxylesterase 1 gene (CES1) encodes a hydrolase that metabolizes
commonly used drugs. The CES1-related pseudogene, carboxylesterase 1 pseudogene 1 …
commonly used drugs. The CES1-related pseudogene, carboxylesterase 1 pseudogene 1 …
The impact of human CES1 genetic variation on enzyme activity assessed by ritalinic acid/methylphenidate ratios
C Stage, K Dalhoff, HB Rasmussen… - Basic & clinical …, 2019 - Wiley Online Library
The present clinical trial investigated the impact of selected SNPs in CES1 on the metabolic
activity of the enzyme. For this purpose, we used methylphenidate (MPH) as a …
activity of the enzyme. For this purpose, we used methylphenidate (MPH) as a …
Clinical implications of genetic variation in carboxylesterase drug metabolism
Introduction: Mammalian carboxylesterase enzymes are a highly conserved metabolic
pathway involved in the metabolism of endogenous and exogenous compounds including …
pathway involved in the metabolism of endogenous and exogenous compounds including …