Background Inherited mutations in the BRCA1 gene are associated with a high risk of breast
and ovarian cancer in some families. However, little is known about the contribution of …

Breast cancer is a rare disease in men, affecting less than 0.1% of the male population. Two
heritable gene defects have been associated with a predisposition to male breast cancer …

Background BRCA1 and BRCA2 pathogenic variants (PVs) are associated with prostate
cancer (PCa) risk, but a wide range of relative risks (RRs) has been reported. Methods We …

Background To define the incidence of BRCA1 mutations among patients seen in clinics that
evaluate the risk of breast cancer, we analyzed DNA samples from women seen in this …

The association of germline mutations in the breast cancer susceptibility gene 1 (BRCA1)
and the breast cancer susceptibility gene 2 (BRCA2) with the development of breast and …

The lifetime risk of breast cancer may approach 80–90% in women who have germline
mutations of either of two genes, BRCA1 or BRCA2 (refs. 1–3). A single BRCA1 mutation …

Background: Heritable mutations of the breast cancer gene BRCA1 are rare, occurring in
fewer than 1% of women in the general population, and therefore account for a small …

Background The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer
(MBC) in the United Kingdom is not known, and the importance of these genes in the …

Background Inherited mutations in DNA-repair genes such as BRCA2 are associated with
increased risks of lethal prostate cancer. Although the prevalence of germline mutations in …

Purpose To analyze the baseline clinicopathologic characteristics of prostate tumors with
germline BRCA1 and BRCA2 (BRCA1/2) mutations and the prognostic value of those …