The Pd (II)/sulfoxide-2-hydroxypyridine catalytic system shows promising activity in C–H
activation chemistry. In this study, we showcase how this catalytic system solves the problem …

DFT calculations have been combined with experiments to study the mechanism of γ-C
(sp3)–H arylation of aliphatic amines promoted by palladium–glyoxylic acid cooperative …

Amide is one of the most widespread functional groups in organic and bioorganic chemistry,
and it would be valuable to achieve stereoselective C (sp3)− H functionalization in amide …

Density functional theory (DFT) calculations were conducted to elucidate the mechanism of
a novel Pd (II) catalyzed C (sp3)–H activation and the subsequent arylation reactions of …

Pd (II)-catalyzed γ-C (sp3)–H arylation of primary amines is realized by using 2-
hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and …

Nitrogen-containing compounds are the most common structural architectures in drug
candidates, natural and biological products, and small-molecule therapeutics. Within the …

C− H functionalization of aliphatic carboxylic acids without attaching exogenous auxiliary
has been so far limited at the proximal β‐position. In this work, we demonstrate a ligand …

Herein, we report a silver-free Pd (II)-catalyzed C (sp3)–H arylation of saturated bicyclic and
tricyclic amine scaffolds. The reaction provides good yields using a range of aryl iodides and …

A transient directing group (DG) has been successfully applied to assist the activation of C–
H bonds. In this paper, we have performed density functional theory (DFT) calculations to …

An example of using readily available, less reactive aryl bromides as arylating reagents in
the Pd (II)-catalyzed intermolecular arylation of unactivated C (sp3)–H bonds is described …