Abstract Approximately 10%–15% of couples are infertile, and a male factor is involved in
almost half of these cases. This observation is due in part to defects in spermatogenesis …

Traditional gene knock-out approaches using homologous recombination in embryonic stem
cells are routinely used to provide functional information about genes involved in …

The emergence of gene inactivation by homologous recombination methodology in
embryonic stem cells has revolutionized the field of mouse genetics. Indeed, the availability …

Spermatogenesis is a complex developmental process that ultimately generates mature
spermatozoa. This process involves a phase of proliferative expansion, meiosis, and …

Approximately 10-15% of couples experience infertility and male factors contribute to half of
these cases. It was usually thought that infertility cannot be transmitted, but accumulating …

The procedures of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are
routinely used in modern medicine to overcome infertility and, in animal husbandry, to …

Ectopic grafting of testicular tissue is a promising new approach that can be used to
preserve testicular function. This technique has been used recently to differentiate the …

Triple knockout mice were used to investigate the interactions of five genes that were
expressed in meiotic and haploid spermatogenic cells in mice, transition protein 2 (Tnp2) …

Over the past few decades with the rapid advances in embryo and embryonic stem cell
manipulation techniques, transgenic mouse models have emerged as a powerful tool for the …

Transgene insertions in the mouse often cause mutations at chromosomal loci. Analysis of
insertion mutations that cause male sterility may lead to the identification of novel molecular …