The protein products of the fos and jun proto-oncogenes form a heterodimeric complex that
participates in a stable high affinity interaction with DNA elements containing AP-1 binding …

The products of the nuclear oncogenes fos and jun are known to form heterodimers that bind
to DNA and modulate transcription. Both proteins contain a leucine zipper that is important …

THE protein products of the c-fos and c-jun proto-oncogenes (Fos and Jun, respectively)
form a heterodimeric protein complex that interacts with the activator protein-1 (AP-1) …

Mutagenesis of the fos protein supports the hypothesis that a heptad repeat of leucine
residues stabilizes the interaction between the fos and jun proteins. We show that the …

Jun and Fos oncoproteins form a complex that regulates transcription from promoters
containing AP-1 binding sites. The'leucine zipper'domain of both Fos and Jun is necessary …

Gene expression is modulated by the specific interactions of nuclear proteins with unique
regulatory sequences in the genome. Proteins involved in transcriptional regulation seem to …

The Fos protein complex and several Fos-related antigens (FRA) bind specifically to a
sequence element referred to as the HeLa cell activator protein 1 (AP-1) binding site. A …

The DNA‐binding domains of the members of the Fos and Jun families of proteins consist of
a basic region followed by a dimerizing segment with heptad repeats of leucine. Fos‐Jun …

The proto-oncogenes c-fos and c-jun function cooperatively as inducible transcription factors
in signal transduction processes. Their protein products, Fos and Jun, form a heterodimeric …

Abstract A STRUCTURAL motif for DNA-binding proteins, the" leucine zipper", has been
proposed for the jun, fos and myc gene products, the yeast transcriptional activator GCN4 …