Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system
leading to demyelination and axonal/neuronal loss. Cumulating evidence points to a key …

Experimental autoimmune encephalomyelitis is a T cell-mediated demyelinating disease of
the CNS that serves as a model for the human disease multiple sclerosis. Increased …

Multiple sclerosis (MS) is the prototypic inflammatory disease of the central nervous system
(CNS) characterized by multifocal areas of demyelination, axonal damage, activation of glial …

Microglia, the parenchymal brain macrophages of the central nervous system, have
emerged as critical players in brain development and homeostasis. The immune functions of …

Multiple sclerosis (MS) is a chronic, inflammatory autoimmune disease that affects the
central nervous system (CNS) for which there is no cure. In MS, encephalitogenic T cells …

Multiple sclerosis (MS) is an autoimmune disease characterized by mononuclear cell
infiltrates, focal demyelination, and the development of sclerotic plaques within the central …

Background Multiple sclerosis (MS) is a chronic debilitating immune-mediated disease of
the central nervous system (CNS) driven by demyelination and gray matter …

Background Clinical studies of B cell depletion in Multiple Sclerosis (MS) have revealed that
B Lymphocytes are involved in the neuro-inflammatory process, yet it remains unclear how B …

During central nervous system autoimmunity, interactions between infiltrating immune cells
and brain-resident cells are critical for disease progression and ultimately organ damage …

Brain-intrinsic degenerative cascades have been proposed to be an initial factor driving
lesion formation in multiple sclerosis (MS). Here, we identify neurodegeneration as a potent …