In rodents, the chemokine CXCL1 both induces the proliferation and inhibits the migration of
oligodendrocyte precursor cells. We previously reported that in multiple sclerosis, the same …

The etiology of multiple sclerosis (MS) remains unknown. However, both genetic and
environmental factors play important roles in its pathogenesis. While demyelination of axons …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) of putative autoimmune origin. Recent evidence indicates that MS …

T cells have an essential role in the induction of multiple sclerosis and its animal model
experimental autoimmune encephalomyelitis (EAE). Although for CD4+ T cells it is well …

Background Experimental autoimmune encephalomyelitis (EAE) is a mouse model of
multiple sclerosis (MS). It has been shown that Th17 cells are critical for EAE pathogenesis …

Multiple sclerosis (MS) is the prototypical inflammatory disease of the central nervous
system (CNS). MS lesions harbor different immune cells, but the contribution of individual …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …

Intracerebral levels of Transforming Growth Factor beta (TGFβ) rise rapidly during the onset
of experimental autoimmune encephalomyelitis (EAE), a mouse model of Multiple Sclerosis …

Immune–neural interactions dictate both lesion formation and repair in multiple sclerosis
(MS). MS pathogenesis is mediated by the interplay of invading immune cells, neurons, glia …

Neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by
innate immune-mediated inflammation, but functional and mechanistic effects of the …