Animal studies implicate meningeal lymphatic dysfunction in the pathogenesis of
neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease (PD) …

Parkinson's disease is characterized by abundant α-synuclein (α-Syn) neuronal inclusions,
known as Lewy bodies and Lewy neurites, and the massive loss of midbrain dopamine …

Background Abnormal aggregation of brain α-synuclein is a central step in the pathogenesis
of Parkinson's disease (PD), thus, it is reliable to promote the clearance of α-synuclein to …

The pathological hallmark of Parkinson's disease (PD) is the formation of Lewy bodies
containing aggregated alpha-synuclein (α-syn). Although PD is associated with these …

Parkinson's disease is a synucleinopathy that is characterized by motor dysfunction, death of
midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates …

Objective Excessive inflammation in the central nervous system (CNS) and the periphery
can result in neurodegeneration and parkinsonism. Recent evidence suggests that immune …

Parkinson's disease and related synucleinopathies are characterized by the abnormal
accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of …

Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …

The pathological hallmark of synucleinopathies, including Lewy body dementia and
Parkinson's disease (PD), is the presence of Lewy bodies, which are primarily composed of …

The spread of pathological α-synuclein (α-syn) is a crucial event in the progression of
Parkinson's disease (PD). Cell surface receptors such as lymphocyte activation gene 3 …